PHYSIOLOGICAL FACTORS INFLUENCING RADIORUBIDIUM FLUX ACROSS ISOLATED RABBIT MESENTERY

Journal Article · Wed Mar 01 04:00:00 EST 1961 · American Journal of Physiology (U.S.)

OSTI ID:4035660

Berndt, W O; Gosselin, R E

A technique is described for measuring in vitro the permeability of rabbit mesentery to Rb/sup 86/ ion. Equations for passive diffusion are adequate to describe the rubidium flax through this membrane, but unlike passage through collodion, transport through mesentery exhibits a high temperature coeffieient. Mesentery reacts in ways that are analogous in some respects to the behavior- of intact capillaries. For example, the permeability is increased be lowering the extracellular calcium ion concentration or the pH. Hydroxytryptamine (5-HT) also elevates the Rb/sup 86/ flux, an effect that can be reversed by salicylate but not by lysergic acid diethlamide (LSD) The nature of the transport process is discussed, and it is seggested that isolated mesentery may serve as a useful model for predicting chemical effects on capillary permeability. (auth)

• Research Organization: Dartmouth Medical School, Hanover, N.H.
• NSA Number: NSA-15-015350
• OSTI ID: 4035660
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 200; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE