EFFECT OF IRRADIATION ON THE HARD TISSUES OF NEWBORN RATS
The tail and lower extremities of newborn rats were exposed to a single radiation dose of from 600 r to 1,800 r, and the coccygeal bcne and tibia were studied microscopically. The growth rate of these bones was appreciably diminished after irradiation in parallel with the exposed dose. In the control animals the growth rate of the coccygeal bone was greater than that of the tibia. When both bones were irradiated in the same dosage, growth was inhibited more markedly in the coccyx. In the non-irradiated animals the growth rate of the coccyx was greater in the distal part than in the proximal region. In irradiated animals depression of growth was exaggerated in the distal region. In the coccyx showing retarded growth the cartilaginous cells still showed appreciable changes even one month after heavy irradiation. In the control rats the formation of the medullary cavity resulting from erosion by vascular connective tissue was most marked in the proximal coccygeal segments. The erosion of this portion was markedly retarded after irradiation. The diminution of the rate of formation of the medullary cavity was in parallel with the irradiated dose. The changes in the tibia seen after irradiation were essentially the same as in the coccyx, except for the time of appearance. Automatic time-recording methods for detecting changes in the bone tissue will be more effective if periodic injection of acetic acid is made. (Absts. Japan. Med., 1: No. 6, 1961)
- Research Organization:
- Tokyo Medical and Dental Univ.
- NSA Number:
- NSA-15-023321
- OSTI ID:
- 4034803
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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