Multiple-ion-beam time-of-flight mass spectrometer
An innovative approach to increase the throughput of mass spectrometric analyses using a multiple-ion-beam mass spectrometer is described. Two sample spots were applied onto a laser desorption/ionization target and each spot was simultaneously irradiated by a beam of quadrupled Nd:YLF laser radiation (261.75 nm) to produce ions by laser-desorption ionization. Acceleration of the ions in an electric field created parallel ion beams that were focused by two parallel einzel lens systems. After a flight path of 2.34 m, the ions were detected with a microchannel plate-phosphor screen assembly coupled with a charge coupled device camera that showed two resolved ion beams. Time-of-flight mass spectra were also obtained with this detector. Experiments were performed using both metal atom cations (Ti{sup +} and Cr{sup +}) produced by laser desorption/ionization and the molecular ions of two different proteins (myoglobin and lysozyme), created by matrix assisted laser desorption/ionization using an excess of nicotinic acid as matrix.
- Sponsoring Organization:
- (US)
- DOE Contract Number:
- FG03-98ER14879
- OSTI ID:
- 40277832
- Journal Information:
- Review of Scientific Instruments, Vol. 72, Issue 8; Other Information: DOI: 10.1063/1.1380682; Othernumber: RSINAK000072000008003386000001; 046107RSI; PBD: Aug 2001; ISSN 0034-6748
- Publisher:
- The American Physical Society
- Country of Publication:
- United States
- Language:
- English
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