CHROMOSOME CHANGES FOLLOWING IRRADIATION IN MAMMALS

Journal Article · Tue Mar 31 04:00:00 EST 1964 · Annals of the New York Academy of Sciences (U.S.)

DOI:https://doi.org/10.1111/j.1749-6632.1964.tb53580.x· OSTI ID:4025032

Nowell, P C; Hungerford, D A; Cole, L J

Four mice examined three to 18 months after recovery from sublethal x irradiation were found to have stemline of abnormal cells in the marlow, spleen, thymus, and lymph nodes. Clones with demonstrable chromosome abnormalities comprised from 10 to 83% of the dividing cells in these organs, with the same stemline often recognizable in more than one tissue. Both balanced and unbalanced abnormalities were observed. In none of the animals was there evidence of leukemia. Similar changes were seen in leukocyte cultures from two patients who were treated with x rays and /sup 32/P. Chromosome abnormalities reported in radioinduced leukemia are reviewed, and the significance of such abnormalities is discussed. (H.M.G.)

• Research Organization: Univ. of Pennsylvania, Philadelphia
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-019583
• OSTI ID: 4025032
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 114; ISSN ANYAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANIMALS
BIBLIOGRAPHY
BIOLOGY AND MEDICINE
BONE MARROW
CARCINOGENESIS
CHROMOSOMES
CYTOLOGY
IRRADIATION
LETHAL DOSE
LEUCOCYTES
LEUKEMIA
LYMPH SYSTEM
MAN
MICE
NUMERICALS
PHOSPHORUS 32
RADIATION EFFECTS
RADIATION INJURIES
RADIOSENSITIVITY
RADIOTHERAPY
RECOVERY
SPLEEN
STATISTICS
SUSPENSIONS
THYMUS
TISSUES
VARIATIONS
X RADIATION