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Title: Tissue irradiator

Abstract

A tissue irradiator is provided for the in-vivo irradiation of body tissue. The irradiator comprises a radiation source material contained and completely encapsulated within vitreous carbon. An embodiment for use as an in- vivo blood irradiator comprises a cylindrical body having an axial bore therethrough. A radioisotope is contained within a first portion of vitreous carbon cylindrically surrounding the axial bore, and a containment portion of vitreous carbon surrounds the radioisotope containing portion, the two portions of vitreous carbon being integrally formed as a single unit. Connecting means are provided at each end of the cylindrical body to permit connections to blood- carrying vessels and to provide for passage of blood through the bore. In a preferred embodiment, the radioisotope is thulium-170 which is present in the irradiator in the form of thulium oxide. A method of producing the preferred blood irradiator is also provided, whereby nonradioactive thulium-169 is dispersed within a polyfurfuryl alcohol resin which is carbonized and fired to form the integral vitreous carbon body and the device is activated by neutron bombardment of the thulium-169 to produce the beta-emitting thulium-170.

Inventors:
; ;
Publication Date:
Research Org.:
Originating Research Org. not identified
OSTI Identifier:
4024280
Patent Number(s):
PAT-APPL-487,327.; US 3927325
Assignee:
to U.S. Energy Research and Development Administration TIC; NSA-33-026116
NSA Number:
NSA-33-026116
Resource Type:
Patent
Resource Relation:
Patent File Date: 1974 Jul 10; Other Information: A61N5/12; G01N21/24; G21G4/00. Orig. Receipt Date: 30-JUN-76
Country of Publication:
United States
Language:
English
Subject:
N47310* -Isotope & Radiation Source Technology-Radiation Sources-Design & Fabrication; 070201* -Isotope & Radiation Source Technology-Radiation Sources-Design & Fabrication; *RADIATION SOURCE IMPLANTS- DESIGN; BLOOD; IN VIVO; RADIOTHERAPY; THULIUM 170; TISSUES

Citation Formats

Hungate, F.P., Riemath, W.F., and Bunnell, L.R. Tissue irradiator. United States: N. p., 1975. Web.
Hungate, F.P., Riemath, W.F., & Bunnell, L.R. Tissue irradiator. United States.
Hungate, F.P., Riemath, W.F., and Bunnell, L.R. Tue . "Tissue irradiator". United States. doi:.
@article{osti_4024280,
title = {Tissue irradiator},
author = {Hungate, F.P. and Riemath, W.F. and Bunnell, L.R.},
abstractNote = {A tissue irradiator is provided for the in-vivo irradiation of body tissue. The irradiator comprises a radiation source material contained and completely encapsulated within vitreous carbon. An embodiment for use as an in- vivo blood irradiator comprises a cylindrical body having an axial bore therethrough. A radioisotope is contained within a first portion of vitreous carbon cylindrically surrounding the axial bore, and a containment portion of vitreous carbon surrounds the radioisotope containing portion, the two portions of vitreous carbon being integrally formed as a single unit. Connecting means are provided at each end of the cylindrical body to permit connections to blood- carrying vessels and to provide for passage of blood through the bore. In a preferred embodiment, the radioisotope is thulium-170 which is present in the irradiator in the form of thulium oxide. A method of producing the preferred blood irradiator is also provided, whereby nonradioactive thulium-169 is dispersed within a polyfurfuryl alcohol resin which is carbonized and fired to form the integral vitreous carbon body and the device is activated by neutron bombardment of the thulium-169 to produce the beta-emitting thulium-170.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 16 00:00:00 EST 1975},
month = {Tue Dec 16 00:00:00 EST 1975}
}