INFLUENCE OF $beta$-MERCAPTOETHYLAMINE ON MUCOSAL UPTAKE OF $sup 59$Fe BY INTESTINE-IRRADIATED RATS

Journal Article · Sun Sep 01 00:00:00 EDT 1963 · Intern. J. Radiation Biol.

OSTI ID:4021976

Prasad, K N; Osborne, J W

A perfusion technlque was used for the study of mucosal uptake of Fe by the irradiated small intestine. The entire exteriorized jejunum and ileum were exposed to 1400 or 1800 r alone, or 1800 r preceded by mercaptoethylamine (MEA) (100 mg/kg I.P.). The decreases in mucosal uptake of /sup 59/Fe were similar in the above categories for the first three days. The mucosal uptake after MEA and 1800 r was much higher at all times after day three than in animals given 1400 r a1one, but on a histological basis, the intestines of both irradiated groups were similar throughout a 20-day period after irradiation. Thus there is a difference between the rate of histological and physiological recovery in the two groups. The sham-irradiated controls with MEA showed 16% mucosal uptake of Fe one day after surge ry, but returned to the control level three days later. The sham- irradiated contro1s without MEA showed 17% mucosal uptake of Fe one day after surgery, but did not return to the control level until six days later. The animals which had the abdominal surgery necessary for perfusion maintained a 9% mucosal uptake over a 20-day period. (auth)

• Research Organization: Univ. of Iowa, Iowa City
• NSA Number: NSA-18-019787
• OSTI ID: 4021976
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 7
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINES
BIOLOGY AND MEDICINE
CYTOLOGY
DIFFUSION
EFFICIENCY
ETHYL RADICALS
INTESTINE
IRON 59
IRRADIATION
MEA
MEDICINE
METABOLISM
ORGANIC SULFUR COMPOUNDS
PERFORMANCE
PHYSIOLOGY
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RATS
RECOVERY
STANDARDS
SURGERY
TESTING
TISSUES
TRACER TECHNIQUES
VARIATIONS