MODIFICATION OF IRRADIATION INJURY IN THE MONKEY BY BONE MARROW TRANSPLANTATION
Journal Article
·
· Blood (U.S.)
OSTI ID:4020293
Thirty-two adult monkeys were given a single dose of total-body x irradiation of 650. 700, or 800 r. An attempt was made in 24 of the animals to alter the acute phase of the radiation injury to hencatopoietic tissues sufficiently to prolong the life of the animals by post-irradiation administration of homologous bone marrow. The other 8 animals served as irradiated non-treated controls. Of the 24 bone marrow treated monkeys, 5 survived for more than 30 days post-irradiation. However, a total of 16 animals showed some recovery of the peripheral blood elements toward normal, which seems to indicate that the bone marrow grait may have been functional in these animals. The causes of death in the face of a recovering bone marrow are discussed with regard to immunological reactions, including the "foreign bone marrow reaction," and other contributing factors. (auth)
- Research Organization:
- Univ. of Tennessee Medical Units, Memphis
- NSA Number:
- NSA-15-016860
- OSTI ID:
- 4020293
- Journal Information:
- Blood (U.S.), Journal Name: Blood (U.S.) Vol. Vol: 17; ISSN BLOOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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