Radioisotope research, production, and processing at the University of Missouri Research Reactor

Journal Article · Sun Dec 31 04:00:00 EST 1995 · Radioactivity and Radiochemistry

OSTI ID:401765

Ehrhardt, G J; Ketring, A R; Ja, Wei; Ma, D; Zinn, K; Lanigan, J

The University of Missouri Research Reactor (MURR) is a 10 MW, light-water-cooled and moderated research reactor which first achieved criticality in 1996 and is currently the highest powered university-owned research reactor in the U.S. For many years a major supplier of reactor-produced isotopes for research and commercial purposes, in the last 15 years MURR has concentrated on development of reactor-produced beta-particle emitters for experimental use in nuclear medicine therapy of cancer and rheumatoid arthritis. MURR has played a major role in the development of bone cancer pain palliation with the agents {sup 153}Sm EDTMP and {sup 186}Re/{sup 188}Re HEDP, as well as in the use of {sup 186}Re, {sup 177}Lu, {sup 166}Ho, and {sup 105}Rh for radioimmunotherapy and receptor-agent-guided radiotherapy. MURR is also responsible for the development of therapeutic, {sup 90}Y-labeled glass microspheres for the treatment of liver tumors, a product ({sup 90}Y Therasphere{trademark}) which is currently an approved drug in Canada. MURR has also pioneered the development of {sup 188}W/{sup 188}Re and {sup 99}Mo/{sup 99m}Tc gel generators, which make the use of low specific activity {sup 188}W and {sup 99}Mo practical for such isotope generators.

• OSTI ID: 401765
• Journal Information: Radioactivity and Radiochemistry, Journal Name: Radioactivity and Radiochemistry Journal Issue: 4 Vol. 6; ISSN RARAE6; ISSN 1045-845X
• Country of Publication: United States
• Language: English

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