THE ULTRASTRUCTURE OF THE KIDNEY IN LEAD INTOXICATION WITH PARTICULAR REFERENCE TO INTRANUCLEAR INCLUSIONS
Journal Article
·
· American Journal of Pathology (U.S.)
OSTI ID:4011795
The specific effect of inorganic lead upon the rat kidney was apparently limited to the cells of the proximal convoluted tubules, where its major pathologic manifestations were the production of intranuclear inclusions and degenerative changes in the cytoplasm. With chrome-osmium fixation, the inclusion ultrastructurally consisted of 3 portions, viz.: a compact core; a looser, beaded, filamentous periphery; and scattered electron-dense particles. Metallic or ionic lead could not be demonstrated, and the inclusion developed independently of the nucleolus. Electron microscopically, the inclusion produced by lead was quite different from intranuclear inclusions of viral origin, which usually are associated with infective particles. (auth)
- Research Organization:
- Washington Univ. School of Medicine, St. Louis
- NSA Number:
- NSA-15-025829
- OSTI ID:
- 4011795
- Journal Information:
- American Journal of Pathology (U.S.), Journal Name: American Journal of Pathology (U.S.) Vol. Vol: 39; ISSN AJPAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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