Mink liver TEQs and reproductive NOAEL resulting from dietary exposure to fish from Saginaw Bay
- National Biological Survey, Columbia, MO (United States). National Fisheries Contaminant Research Center
- Fish and Wildlife Service, Arlington, VA (United States). Division of Environmental Contaminants
- Michigan State Univ., East Lansing, MI (United States)
Mink are known to be very sensitive to the toxic effects of planar halogenated hydrocarbons (PHHs). Previously the authors reported the reproductive effects in mink fed a diet containing 10, 20, or 40% fish taken from Saginaw Bay, Lake Huron. In this presentation the authors report the complete chemical analyses of the diets and the adult mink livers, along with a comparison of an additive model of toxicity with the results of the H411E bioassay on these samples. The H411E bioassay consistently estimated greater dioxin toxic-equivalents (TEQS) as compared to an additive model of toxicity and chemical analyses. TEQs derived from chemical analyses accounted for approximately 60% of the TEQs observed with the H411E bioassay. The difference is likely due to the presence of compounds which were not quantitated as opposed to synergistic interactions of the mixtures. Significant reproductive effects were observed in the lowest treatment group (10% fish, or 19.4 pg TEQs/g). The implications of these chemical and bioassay analyses on the calculation of a NOAEL will be discussed.
- OSTI ID:
- 40034
- Report Number(s):
- CONF-9410273--
- Country of Publication:
- United States
- Language:
- English
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