Evidence that MFO induction in fish exposed to BKME is not linked to PCDDs/PCDFs
- Univ. of Waterloo, Ontario (Canada)
- Department of Fisheries and Oceans, Burlington, Ontario (Canada)
- Univ. of Guelph, Ontario (Canada)
The involvement of PCDDs and PCDFs in mixed function oxygenase (MFO) induction observed in fish exposed to bleached kraft mill effluent (BKME) has been an area of controversy. In spring of 1993 wild white sucker captured at Jackfish Bay (BKME exposed) and Mountain Bay (reference) were caged in the effluent plume of a BKME receiving area (Jackfish Bay). Spawning fish from both sites initially had equally low liver MFO activity and demonstrated a twenty-fold increase in activity upon BKME exposure within two days. This activity remained constant through 4 and 8 days. Levels of plasma steroid hormones and plasma gonadotropin (GTHII) were also measured but these data were inconclusive due to stress effects. To measure exposure which was relevant to MFO induction, the H411E cell culture bioassay for measuring 2,3,7,8-TCDD toxic equivalent concentration (TEC) was utilized. Bioassay data revealed that Jackfish bay males had TECs of approximately 50 pg g{sup {minus}1} for both BKME caged and cage control fish. Mountain Bay fish were initially significantly lower (15 pg g{sup {minus}1}) but did show a significant increase when exposed to effluent. These data when coupled with dioxin and furan chemical residue data strongly suggest that less lipophilic compounds are likely responsible for the MFO induction observed.
- OSTI ID:
- 40030
- Report Number(s):
- CONF-9410273-; TRN: IM9520%%225
- Resource Relation:
- Conference: 15. annual meeting of the Society of Environmental Toxicology and Chemistry (SETAC), Denver, CO (United States), 30 Oct - 3 Nov 1994; Other Information: PBD: 1994; Related Information: Is Part Of Society of Environmental Toxicology and Chemistry 15th annual meeting: Abstract book. Ecological risk: Science, policy, law, and perception; PB: 286 p.
- Country of Publication:
- United States
- Language:
- English
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