The use of body-residue based modeling for estimating toxicity of chemical mixtures to fish
- Univ. of Waterloo, Ontario (Canada)
A general lack of understanding and inadequate predictive models of toxicant interactions have made it difficult for regulatory agencies to provide water quality guidelines that effectively address toxicant mixtures. The authors are using a whole-body residue based first-order kinetic model to examine the combined effects of toxicants on aquatic systems. The use of a kinetic model allows us to separate and study two important aspects involved in the interaction of toxicant mixtures. First, the influence of one chemical on the kinetics of the other i.e. the effect on uptake and/or deputation. Secondly, the influence of one chemical on the resulting toxicity of the other once they have reached their respective sites of toxic action. Kinetic studies with juvenile Rainbow trout (Oncorhynchus mykiss) exposed to chlorinated benzenes and phenols indicate that the uptake and deputation of these chemicals does fit a 1CFOK model. Studies using binary mixtures of these chemicals (which have different modes of toxic action) have shown that at sublethal concentrations, the kinetics for each chemical in the mixture is not significantly different from when it is present alone. The second aspect will be addressed by comparing critical body residues and times-to-death from single chemical bioassays to binary mixture bioassays using a model based on strict addition.
- OSTI ID:
- 40021
- Report Number(s):
- CONF-9410273-; TRN: IM9520%%216
- Resource Relation:
- Conference: 15. annual meeting of the Society of Environmental Toxicology and Chemistry (SETAC), Denver, CO (United States), 30 Oct - 3 Nov 1994; Other Information: PBD: 1994; Related Information: Is Part Of Society of Environmental Toxicology and Chemistry 15th annual meeting: Abstract book. Ecological risk: Science, policy, law, and perception; PB: 286 p.
- Country of Publication:
- United States
- Language:
- English
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