Biological studies with laser-polarized

Journal Article · Wed May 01 04:00:00 EDT 1996 · Bulletin of the American Physical Society

OSTI ID:394185

Tseng, C H; Oteiza, E R; Wong, G A; Walsworth, R I ^[1]

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1. and others

The authors have studied several biological systems using laser-polarized {sup 129}Xe. In certain tissues magnetic resonance imaging (MRI) using inhaled laser-polarized noble gases may provide images superior to those from conventional proton MRI. High resolution laser-polarized {sup 3}He images of air spaces in the human lung were recently obtained by the Princeton/Duke group. However, {sup 3}He is not very soluble in tissue. Therefore, the authors are using laser polarized {sup 129}Xe (tissue-soluble), with the long term goal of biomedical functional imaging. They have investigated multi-echo and multi-excitation magnetic resonance detection schemes to exploit the highly non-thermal {sup 129}Xe magnetization produced by the laser polarization technique. They have inhalated live rats with laser-polarized {sup 129}Xe gas and measured three distinct {sup 129}Xe tissue resonances that last 20 to 40 sec. As a demonstration, the authors obtained a laser polarized {sup 129}Xe image of the human oral cavity. Currently they are measuring and polarization lifetime of {sup 129}Xe dissolved in human blood, the biological transporting medium. These studies are other recent developments will be reported.

• OSTI ID: 394185
• Report Number(s): CONF-9605105--
• Journal Information: Bulletin of the American Physical Society, Journal Name: Bulletin of the American Physical Society Journal Issue: 3 Vol. 41; ISSN BAPSA6; ISSN 0003-0503
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BLOOD CIRCULATION
IMAGES
MAGNETIC RESONANCE
ORAL CAVITY
POLARIZATION
TOMOGRAPHY
UPTAKE
XENON 129