Toxicity of 2,4,4{prime}-trichlorobiphenyl in rats following 90-day dietary exposure

Journal Article · Fri Oct 25 04:00:00 EDT 1996 · Journal of Toxicology and Environmental Health

DOI:https://doi.org/10.1080/00984108.1996.11667603· OSTI ID:394098

Chu, I; Villeneuve, D C; Yagminas, A; Lecavalier, P; Poon, R ^[1]

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1. Environmental Health Directorate, Ontario (Canada); and others

The toxicity of 2,4,4{prime}-trichlorobiphenyl (PCB 28) was investigated in rats after a 90-d dietary exposure. Groups of 10 male and 10 female weanling Sprague-Dawley rats were administered PCB 28 in the diet at 0, 0.05, 0.50, 5.0, or 50.0 ppm for 13 wk. Growth rate and food consumption were not affected by treatment, and no clinical signs of toxicity were observed. Mottled liver was noted in both control and PCB-treated males, but was found with increased incidence in the highest treatment group. Increased urinary ascorbic acid and hepatic microsomal ethoxyresorufin O-deethylase activity were observed in the 50.0 ppm group of both sexes. The vitamin A content in liver, lung, and kidney was not significantly affected by treatment. Analysis of brain biogenic amines showed a decreased dopamine concentration in the substantial nigra region of female rats receiving 0.5 ppm PCB 28 and higher doses. Female rats appeared top be more sensitive than males to the neurochemical effects of PCB 28. Dose-dependent histologic changes were observed in the thyroid and liver, with biologically significant changes occurring at 5.0 ppm and above. Based on these data, the no-observable-adverse-effect level (NOAEL) for this PCB congener was considered to be 0.5 ppm in diet or 36 {mu}g/kg body weight/d. 26 refs., 6 figs., 3 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 394098
• Journal Information: Journal of Toxicology and Environmental Health, Journal Name: Journal of Toxicology and Environmental Health Journal Issue: 3 Vol. 49; ISSN 0098-4108; ISSN JTEHD6
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
POLYCHLORINATED BIPHENYLS
RATS
TOXICITY