Diurnal urinary volume and uranium output in uranium workers and unexposed controls
- Univ. of Washington, Seattle, WA (United States)
- CHEMCHEK Instruments, Inc., Richland, WA (United States)
Volume and uranium content were determined in individual urine voids over a 76-h (3.25-d) period from six unexposed normal male subjects and three male uranium workers. Uranium analyses were accomplished by a newly developed high-precision kinetic phosphorescence analysis technique with a lower level of detection of 0.007 ng mL{sup {minus}1}. Urinary uranium concentrations in individual voids varied by a factor of 2 or less for any one unexposed subject, although there was an order of magnitude variation among the group of unexposed men. The fractional urinary volume excreted in the {open_quotes}standard{close_quotes} so-called simulated 24-h sample was the same for both the unexposed and exposed groups and averaged 0.42 {+-} 0.13 of the total daily urine volume. The fraction of uranium in the simulated 24-h samples was 0.43 {+-} 0.15 in the unexposed group but only 0.31 {+-} 0.13 in the uranium worker group, suggesting that the use of the simulated 24-h urine sample would underestimate the total daily urinary uranium output by approximately a factor of 2 in the uranium workers. Daily urinary excretion relative to intake from drinking water (essentially equal to the gastrointestinal uptake fraction) among the unexposed group ranged from 0.002-0.028, averaging 0.011 {+-} 0.008, with an indication that the gastrointestinal uptake factor was inversely proportional to total intake via drinking water. 11 refs., 1 fig., 6 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 39408
- Journal Information:
- Health Physics, Journal Name: Health Physics Journal Issue: 2 Vol. 67; ISSN HLTPAO; ISSN 0017-9078
- Country of Publication:
- United States
- Language:
- English
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