Thyroid lesions in children and adolescents after the Chernobyl disaster: Implications for the study of radiation tumorigenesis

Journal Article · Sun Dec 31 23:00:00 EST 1995 · Journal of Clinical Endocrinology and Metabolism

DOI:https://doi.org/10.1210/jc.81.1.9· OSTI ID:393903

Nikiforov, Y; Fagin, J A ^[1]; Gnepp, D R ^[2]

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1. Univ. of California School of Medicine, Los Angeles, CA (United States)
2. Brown Univ. School of Medicine, Providence, RI (United States)

Eight years after the Chernobyl nuclear accident, the most obvious effect is manifested by an increase in the prevalence of thyroid gland diseases in the exposed children and adolescents. In this study, we describe a comparative analysis of epidemiological, clinical, and morphological features of 92 malignant and 59 benign thyroid lesions from patients 5-18 yr of age exposed to radiation in Belarus as a result of the Chernobyl disaster. All of them were operated at the same institution during the period from September 1991 through December 1992. The highest number of patients that subsequently developed thyroid carcinomas was in the group that was less that 1 yr of age at the time of Chernobyl, and this number decreased progressively through age 12 yr. Conversely, none of the patients with benign lesions only was less than 2 yr old at the time of the accident, and an exposure age of 5-6 yr was a threshold separating significant prevalence of malignant tumors in younger children from the more frequently benign lesions in older patients (P {le} 0.001). Fifty-two percent of the children with carcinomas and only 24% with benign lesions (P {le} 0.005) were residents of the Gomel region, which is the most contaminated in Belarus. The morphology of thyroid tissue adjacent to carcinomas showed a high prevalence of multinodular and diffuse changes, but not of adenomas or solitary adenomatoid nodules. There was a high prevalence of focal micropapillary hyperplasia with graded degrees of severity, which we hypothesize may correspond to precursors for papillary thyroid carcinoma in post-Chernobyl radiation-associated tumors. 36 refs., 3 figs., 4 tabs.

• OSTI ID: 393903
• Journal Information: Journal of Clinical Endocrinology and Metabolism, Journal Name: Journal of Clinical Endocrinology and Metabolism Journal Issue: 1 Vol. 81; ISSN JCEMAZ; ISSN 0021-972X
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
57 HEALTH AND SAFETY
CARCINOGENESIS
CHERNOBYLSK-1 REACTOR
CHILDREN
DELAYED RADIATION EFFECTS
IODINE 131
NEOPLASMS
RADIATION ACCIDENTS
RADIATION DOSES
RADIONUCLIDE KINETICS
RADIOSENSITIVITY
REACTOR ACCIDENTS
RISK ASSESSMENT
THYROID