Preliminary evidence for an association of a dinucleotide repeat polymorphism at the MAOA gene with early onset alcoholism/substance abuse

Journal Article · Mon Apr 24 04:00:00 EDT 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600207· OSTI ID:393893

Vanyukov, M M; Moss, H B; Tarter, R E ^[1]

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1. Univ. of Pittsburg, PA (United States); and others

An association between the liability to early onset alcoholism/substance abuse and a recently discovered dinucleotide repeat length polymorphism at the MAOA gene (MAOCA-1) was examined using polymerase chain reaction (PCR). A significant correlation between the presence/absence of the disorder and the length of the MAOCA-1 repeat was found in males, but not females, with {open_quotes}long{close_quotes} alleles (repeat length above 115 bp) associated with both increased risk for the disorder and lower age of onset of substance abuse. These preliminary data suggest that further exploration of the relationship between the MAOA gene and behavioral traits in an expanded sample is warranted. 22 refs., 1 fig., 3 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 393893
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 2 Vol. 60; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AGE DEPENDENCE
AMINE OXIDASES
BEHAVIOR
DRUG ABUSE
ETIOLOGY
GENE MUTATIONS
GENES
GENETIC MAPPING
GENOTYPE
HEREDITARY DISEASES
HUMAN X CHROMOSOME
MALES
MUTATION FREQUENCY
NUCLEOTIDES
POLYMERASE CHAIN REACTION
RFLPS
RISK ASSESSMENT
STATISTICS