Linkage studies of bipolar disorder in the region of the Darier`s disease gene on chromosome 12q23-24.1

Journal Article · Mon Apr 24 04:00:00 EDT 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600203· OSTI ID:393889

Dawson, E; Lim, L; Sham, P; Gill, M ^[1]

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1. Institute of Psychiatry, London (United Kingdom); and others

We have recently described a family in which there is cosegregation of major affective disorder with Darier`s disease and have mapped this autosomal dominant skin disorder to 12q23-q24.1. This has provided an interesting candidate region for genetic studies of bipolar disorder. We have studied the segregation of seven markers spanning the Darier`s disease locus in 45 bipolar disorder pedigrees and found modest evidence in support of linkage under heterogeneity for 5 of these markers. Nonparametric analyses were suggestive of linkage with a marker at the gene encoding a secretory form of phospholipase A2. Our sample has relatively low power to detect linkage under heterogeneity and independent researchers should examine markers from this region in further samples of bipolar pedigrees. 41 refs., 1 fig., 7 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 393889
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 2 Vol. 60; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
GENES
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HUMAN CHROMOSOME 12
MENTAL DISORDERS
PATIENTS
POLYMERASE CHAIN REACTION
SKIN DISEASES
STATISTICS