Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization
- Scripps Research Institute, La Jolla, CA (United States)
- Yale Univ. School of Medicine, New Haven, CT (United States); and others
Human autoantibodies to intracellular antigens are often found in patients with systemic rheumatic diseases. Our laboratory and others have reported the cloning of the cDNAs for two protein autoantigens. The 60-kDa protein is a member of the RNA binding protein family containing an RNA binding motif and has been shown to be primarily responsible for direct interaction with hY-RNAs. The assignment of the 60-kDa autoantigen gene (SSA2) to 1q31 may allow further investigation of the genetic basis of human autoimmune diseases in which ss-A/Ro antibodies are observed. 14 refs., 1 fig.
- OSTI ID:
- 391789
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 23; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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