A YAC contig spanning the dominant retinitis pigmentosa locus (RP9) on chromosome 7p
- Institute of Ophthalmology, London (United Kingdom); and others
The dominant retinitis pigmentosa locus RP9 has previously been localized to 7p13-p15, in the interval D7S526-D7S484. We now report refinement of the locus to the interval D7S795-D7S484 and YAC contig of approximately 4.8 Mb spanning this region and extending both distally and proximally from it. The contig was constructed by STS content mapping and physically orders 29 STSs in 28 YAC clones. The order of polymorphic markers in the contig is consistent with a genetic map that has been assembled using haplotype data from the CEPH pedigrees. This contig will provide a primary resource for the construction of a transcriptional map of this region and for the identification of the defective gene causing this form of adRP. 27 refs., 3 figs., 1 tab.
- OSTI ID:
- 390659
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 28; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
Similar Records
A YAC contig encompassing the chromosome 7p locus for autosomal dominant retinitis pigmentosa
Further refinement of the location for autosomal dominant retinitis pigmentosa on chromosome 7p (RP9)
Autosomal dominant retinitis pigmentosa: No evidence for nonallelic genetic heterogeneity on 3q
Journal Article
·
Thu Sep 01 00:00:00 EDT 1994
· American Journal of Human Genetics
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OSTI ID:134420
Further refinement of the location for autosomal dominant retinitis pigmentosa on chromosome 7p (RP9)
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Thu Mar 31 23:00:00 EST 1994
· American Journal of Human Genetics; (United States)
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OSTI ID:7105211
Autosomal dominant retinitis pigmentosa: No evidence for nonallelic genetic heterogeneity on 3q
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Sun Jan 31 23:00:00 EST 1993
· American Journal of Human Genetics; (United States)
·
OSTI ID:6572714