Radiobiological challenges posed by microdosimetry

Journal Article · Sat Jun 01 04:00:00 EDT 1996 · Health Physics

DOI:https://doi.org/10.1097/00004032-199606000-00008· OSTI ID:387388

Kellerer, A M ^[1]

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1. Ludwig-Maximilians-Universitate, Muenchen (Germany)

The inapplicability of the concept of dose to cellular and subcellular structures is the paradox that has driven the development of radiation biophysics. It remains a central problem which necessitates the use of microdosimetry in radiobiology, radiation protection, and the clinical applications of ionizing radiation. The trend towards microdosimetric measurements in radiation protection practice is contrasted to the recent adoption of radiation protection quantities by ICRP that are not related to microdosimetric parameters, and it is argued that uncertainties in the numerical magnitude of radiation risks must not motivate ambiguity of definitions. In radiobiology there has been a variety of uses of microdosimetric data but an insufficient assessment of their differences and similarities, often compounded by widely different terminology. The use of microdosimetry in radiobiology of biological information, not by lack of microdosimetric data. New techniques of molecular biology are now beginning to permit analyses of the spatial distribution of DNA lesions that can be correlated to the spatial fluctuations of energy deposition by different ionizing radiations. 32 refs., 4 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 387388
• Journal Information: Health Physics, Journal Name: Health Physics Journal Issue: 6 Vol. 70; ISSN HLTPAO; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL RADIATION EFFECTS
BIOPHYSICS
DNA
ICRP
IONIZING RADIATIONS
MICRODOSIMETRY