An exposure system for measuring nasal and lung uptake of vapors in rats

Technical Report · Fri Dec 01 04:00:00 EST 1995

DOI:https://doi.org/10.2172/381359· OSTI ID:381359

Dahl, A. R.; Brookins, L. K.; Gerde, P. ^[1]

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1. National Inst. for Working Life, Solna (Sweden)

Inhaled gases and vapors often produce biological damage in the nasal cavity and lower respiratory tract. The specific site within the respirator tract at which a gas or vapor is absorbed strongly influences the tissues at risk to potential toxic effects; to predict or to explain tissue or cell specific toxicity of inhaled gases or vapors, the sites at which they are absorbed must be known. The purpose of the work reported here was to develop a system for determining nose and lung absorption of vapors in rats, an animal commonly used in inhalation toxicity studies. In summary, the exposure system described allows us to measure in the rate: (1) nasal absorption and desorption of vapors; (2) net lung uptake of vapors; and (3) the effects of changed breathing parameters on vapor uptake.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 381359
• Report Number(s): ITRI--146; ON: DE96008986; CNN: Grant R01-ES04422
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
GASES
INHALATION
PROGRESS REPORT
RATS
RESPIRATORY SYSTEM
UPTAKE