The human growth hormone gene is regulated by a multicomponent locus control region
Journal Article
·
· Molecular and Cellular Biology
- Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)
This article describes research involving the five-member human growth hormone (hGH)/chorionic somatomammotropin (hCS) gene cluster and its expression in the placenta. The results indicate that interactions among multiple elements are required to restrict hGH transcription to the pituitary and generate appropriate levels of expression in the mouse genome. In addition, the results suggest a role for shared and unique regulatory sequences in locus control region-mediated expression of the hGH/hCS gene cluster in the pituitary and possibly the placenta. 67 refs., 9 figs.
- OSTI ID:
- 379248
- Journal Information:
- Molecular and Cellular Biology, Vol. 15, Issue 12; Other Information: PBD: Dec 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Analysis of mammary specific gene locus regulation in differentiated cells derived by somatic cell fusion
An efficient expression of Human Growth Hormone (hGH) in the milk of transgenic mice using rat {beta}-casein/hGH fusion genes
Molecular basis of human growth hormone gene deletions
Journal Article
·
Sun Feb 01 00:00:00 EST 2009
· Experimental Cell Research
·
OSTI ID:379248
An efficient expression of Human Growth Hormone (hGH) in the milk of transgenic mice using rat {beta}-casein/hGH fusion genes
Journal Article
·
Fri Mar 01 00:00:00 EST 1996
· Applied Biochemistry and Biotechnology
·
OSTI ID:379248
Molecular basis of human growth hormone gene deletions
Journal Article
·
Mon Aug 01 00:00:00 EDT 1988
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
·
OSTI ID:379248
+1 more