Homologous gene family database compilation

Conference · Thu Dec 30 23:00:00 EST 1993

OSTI ID:37761

Lim, H A ^[1]; Shindyalov, I N ^[2]

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1. Florida State Univ., Tallahassee, FL (United States)
2. Columbia Univ., New York, NY (United States). Dept. of Biochemistry and Molecular Biophysics

Studies of homolog evolution and interpretation of mutational patterns are useful approaches for investigating the structural and functional information contained in sequences. To increase the accuracy and reliability of these approaches, a systematic comparative analysis of the evolutionary modes of sequence families is needed. The first step in such an analysis is the compilation of possible families from databases. The goal of this work is to develop algorithms and software for compiling homologous genes coding for proteins from the GenBank database. Stages in the database compilation are described, and the resulting database is used for studying evolutionary modes of gene families.

• DOE Contract Number: FG05-85ER25000; FG05-92ER61500
• OSTI ID: 37761
• Report Number(s): CONF-9206273--; ISBN 981-02-1157-0
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACID SEQUENCE
BIOLOGICAL EVOLUTION
DATA BASE MANAGEMENT
GENE MUTATIONS
GENES
GENETIC MAPPING
INFORMATION SYSTEMS
MAN
PROTEINS