Whole body gamma radiation and marrow sensitivity: A comparative study between adult rats of eight different strains

Conference · Tue Oct 01 00:00:00 EDT 1996

OSTI ID:370097

Smith, G S; Elshafie, M S; Abdelrahman, H G ^[1]

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1. Tuskegee Univ., AL (United States)

Rats of Fischer-344 strain is quite resistant to whole-body gamma radiation. There is a genetic difference in rat hemoglobin (Hb) {beta}-chain structure, with alternate alleles, A and B, at a single locus. This study was designed to find out whether marrow sensitivity due to sublethal gamma exposure in age matched adult rats is entirely strain specific or a combination of both strain and Hb genotype specific. Eight strains of rats comprising of Hb genotypes AA and BB were studied. Several hematological parameters reflecting marrow evaluation were analyzed and compared. The data to be presented indicate that there is a partial but distinct relationship between radiosensitivity and Hb genotypes.

• OSTI ID: 370097
• Report Number(s): CONF-960376--
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL RADIATION EFFECTS
GAMMA RADIATION
GENOTYPE
HEMOGLOBIN
RADIOSENSITIVITY
RATS
STRAINS
WHOLE-BODY IRRADIATION