Molecular modeling study of uranyl nitrate extraction with monoamides. 2: Molecular mechanics and lipophilicity calculations -- Structure-activity relationships

Journal Article · Fri Jan 01 04:00:00 EST 1999 · Solvent Extraction and Ion Exchange

DOI:https://doi.org/10.1080/07360299908934602· OSTI ID:343781

Rabbe, C; Madic, C ^[1]; Sella, C ^[2]; Godard, A ^[3]

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1. CEA-DCC-DRRV, Bagnols-sur-Ceze (France)
2. E.S.P.C.I., Paris (France). Lab. de Chimie Analytique
3. INSA Rouen, Mont-Saint-Aignan (France)

This report describes the second part of a theoretical approach aimed at establishing structure-activity relationships in a data base made of twenty-two monoamides (A) used as uranium (VI) nitrate extractants. It was found that predominant factors determining the extracting ability of a monoamide are of three kinds: (1) electron density of the coordinating atoms or groups, which should be as high as possible; (2) steric effects, which should be as low as possible; and (3) lipophilicity of the ligands, which should be above a minimum threshold value. In the first paper of this series, quantum chemistry calculations were reported to account for electronic properties of the ligands. This second paper reports molecular mechanics calculations made on UO{sub 2}(NO{sub 3}){sub 2}A{sub 2} complexes in order to determine the influence of steric effects on the formation of these compounds. Calculations of monoamide lipophilicity using Rekker`s method showed that all the molecules of the data base were lipophilic enough and, consequently, that this parameter was not significantly important for the extraction of uranyl nitrate by these monoamides. A quantitative relationship was established between the U(VI) distribution ratio and the two parameters, calculated by quantum chemistry and molecular mechanics methods.

• Sponsoring Organization: USDOE
• OSTI ID: 343781
• Journal Information: Solvent Extraction and Ion Exchange, Journal Name: Solvent Extraction and Ion Exchange Journal Issue: 1 Vol. 17; ISSN 0736-6299; ISSN SEIEDB
• Country of Publication: United States
• Language: English

Related Subjects

05 NUCLEAR FUELS
32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATION
40 CHEMISTRY
AMIDES
MOLECULAR MODELS
MOLECULAR STRUCTURE
REPROCESSING
SOLVENT EXTRACTION
STRUCTURE-ACTIVITY RELATIONSHIPS
URANYL NITRATES