{sup 99}Tc bioassay: A direct comparison of liquid scintillation radiation detection and ICP-MS mass detection of the {sup 99}Tc isotope

Conference · Thu Dec 31 04:00:00 EST 1998

OSTI ID:338629

Lewis, L A ^[1]; Schweitzer, G K ^[2]

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1. Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States). Analytical Services Organization
2. Univ. of Tennessee, Knoxville, TN (United States). Dept. of Chemistry

A means of analyzing {sup 99}Tc in urine by inductively coupled plasma mass spectrometry (ICP-MS) has been developed. Historically, {sup 99}Tc analysis was based on the radiometric detection of the 293 keV E{sub Max.} beta decay product by liquid scintillation or gas flow proportional counting. A separation scheme for {sup 99}Tc detection by ICP-MS is given and is proven to be a sensitive and robust analytical alternative. A comparison of methods using radiometric and mass quantitation of {sup 99}Tc has been conducted in water, artificial urine, and real urine matrices at activity levels between 700 and 2,200 dpm/L. Liquid scintillation results based on an external standard manual quench correction and an automatic quench curve correction method are compared with results obtained by ICP-MS. Each method produced accurate results; however, the precision of the ICP-MS results is superior to that of liquid scintillation results.

• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 338629
• Report Number(s): CONF-980310--
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOASSAY
COMPARATIVE EVALUATIONS
ICP MASS SPECTROSCOPY
SCINTILLATION COUNTING
TECHNETIUM 99
URINE