Some problems in the skeletal dosimetry of bone-seeking radionuclides
- Univ. of Utah, Salt Lake City, UT (United States). Radiobiology Div.
- Pacific Northwest National Lab., Richland, WA (United States)
- Madison Research Group, Inc., Willowbrook, IL (United States)
There are fundamental problems with the calculation of radiation doses to the skeleton from internal emitters deposited in bone. Some of these include dose inhomogeneities, identity of cells at risk and their dynamics, changing deposition patterns of bone-seeking radionuclides ({sup 239}Pu; {sup 90}Sr) with time after exposure, seemingly unique responses of the skeleton to each deposited radionuclide, the role of radioactive progeny produced by deposited emitters and their individual dynamics and effects, different responses of mammals of different ages at exposure to identical dosages, different responses to different chemical forms of a given radionuclide, and different responses to an identical dose from a given radionuclide at different dose-rates. This situation makes it necessary to choose some common dose parameter that will allow the overall effects of different radionuclides to be compared directly so that projected effects of each of them in humans can be estimated. For radiation protection purposes, it appears premature to abandon the concept of average skeletal dose (which appears to be a practical compromise for use) until an undelusive, non-artificial and uncontrived method of calculating absorbed dose to the appropriate cells in bone is developed that fulfills the requirement of equal cancer response for equal skeletal dose for all circumstances.
- Sponsoring Organization:
- USDOE, Washington, DC (United States); National Cancer Inst., Bethesda, MD (United States)
- OSTI ID:
- 332717
- Journal Information:
- Health Physics, Vol. 76, Issue 4; Other Information: PBD: Apr 1999
- Country of Publication:
- United States
- Language:
- English
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