Uptake, distribution and elimination of {sup 54}Mn(II) in the brown trout (Salmo trutta)
- Univ. du Quebec, Rimouski, Quebec (Canada). Dept. d`oceanographie
- Swedish Univ. of Agricultural Sciences, Uppsala (Sweden)
- INRS-Oceanologie, Rimouski, Quebec (Canada)
Brown trout (Salmo trutta) were exposed to water containing 0.1 {mu}g {center_dot} L{sup {minus}1} (1.8 nmol {center_dot} L{sup {minus}1}) of {sup 54}Mn(II) for 1, 3, or 6 weeks. Additional trout were exposed for 3 weeks and allowed to depurate for 1 or 3 weeks. Both the uptake and the organ distribution of manganese (Mn) were determined by gamma counting and whole-body autoradiography. Steady-state concentration, C{sub SS}, and biological half-life, t{sub 1/2}, were calculated. The whole-body Mn concentration reached after 6 weeks of exposure was close to C{sub SS} and t{sub 1/2} was 9.6 d. Manganese concentration in tissues followed the decreasing order liver > viscera without liver and key > gills > skin, fins, bones, and head excluding gills, brain, and eyes > kidney {approx} epidermal mucus > brain > eyes > muscle. Autoradiograms indicated high Mn concentrations in the pancreatic tissue, skeleton, gastrointestinal mucosa, and olfactory system. Gills, viscera, and eyes were near steady state after 6 weeks of exposure, while the other tissues were not. The depuration rate of total radioactivity was relatively rapid initially as 22% of Mn content was lost during the first week, and became slower in the following 2 weeks. Participation of Mn in enzymatic activities of liver, pancreas, and gastrointestinal mucosa may explain its high uptake in these tissues, whereas accumulation in the skeleton seems to be related to bone formation. The uptake of Mn by way of olfactory system favored its accumulation in the brain of trout. As Mn is known to be neurotoxic, the authors suggest this route of uptake could be of toxicological significance for fish.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 31813
- Journal Information:
- Environmental Toxicology and Chemistry, Journal Name: Environmental Toxicology and Chemistry Journal Issue: 3 Vol. 14; ISSN 0730-7268; ISSN ETOCDK
- Country of Publication:
- United States
- Language:
- English
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