Modeling the effects of annual influenza vaccination

Technical Report · Thu Dec 31 04:00:00 EST 1998

DOI:https://doi.org/10.2172/314169· OSTI ID:314169

Smith, D J; Ackley, D H; Forrest, S ^[1]; Perelson, A S ^[2]

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1. Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Computer Science
2. Los Alamos National Lab., NM (United States). Theoretical Div.

Although influenza vaccine efficacy is 70--90% in young healthy first-time vaccinees, the efficacy in repeat vaccinees has varied considerably. In some studies, vaccine efficacy in repeat vaccinees was higher than in first-time vaccinees, whereas in other studies vaccine efficacy in repeat vaccinees was significantly lower than in first-time vaccinees and sometimes no higher than in unvaccinated controls. It is known that the closeness of the antigenic match between the vaccine strain and the epidemic virus is important for vaccine effectiveness. In this study the authors show that the antigenic differences between a first vaccine strain and a second vaccine strain, and between the first vaccine strain and the epidemic strain, might account for the observed variation in attack rate among two-time vaccinees.

• Research Organization: Los Alamos National Lab., Theoretical Div., NM (United States)
• Sponsoring Organization: USDOE Assistant Secretary for Management and Administration, Washington, DC (United States); Santa Fe Inst., NM (United States); Office of Naval Research, Washington, DC (United States); National Science Foundation, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 314169
• Report Number(s): LA-UR--98-2924; CONF-981019--; ON: DE99001780; CNN: Grant ONR N00014-95-1-0364; Grant NSF IRI-9157644
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ANTIGEN-ANTIBODY REACTIONS
EPIDEMIOLOGY
EXPERIMENTAL DATA
GENETIC VARIABILITY
INFLUENZA
INFLUENZA VIRUSES
INOCULATION
MATHEMATICAL MODELS
PREVENTIVE MEDICINE
VACCINES