NMR microscopy of trabecular bone and its role in skeletal dosimetry
- Univ. of Florida, Gainesville, FL (United States). Brain Inst.
One of the more intractable problems in internal dosimetry is the assessment of energy deposition by alpha and beta particles within trabecular, or cancellous, bone. In the past few years, new technologies have emerged that allow for the direct and nondestructive 3D imaging of trabecular bone with sufficient spatial resolution to characterize trabecular bone structure in a manner needed for radiation dosimetry models. High-field proton nuclear magnetic resonance (NMR) imaging is one such technology. NMR is an ideal modality for imaging trabecular bone due to the sharp contrast in proton density between the bone matrix and bone marrow regions. In this study, images of the trabecular regions within the bodies of human thoracic vertebra have been obtained at a field strength of 14.1 T. These images were digitally processed to measure chord length distribution data through both the bone trabecular and marrow cavities. These distributions, which were found to be qualitatively consistent with those measured by F.W. Spiers and colleagues at the University of Leeds using physical sectioning and automated light microscopy, yielded a mean trabecular thickness of 201 {micro}m and a mean marrow cavity thickness of 998 {micro}m. The NMR techniques developed here for vertebral imaging may be extended to other skeletal sites, allowing for improved site-specific skeletal dosimetry.
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC05-76OR00033
- OSTI ID:
- 302295
- Journal Information:
- Health Physics, Journal Name: Health Physics Journal Issue: 6 Vol. 75; ISSN HLTPAO; ISSN 0017-9078
- Country of Publication:
- United States
- Language:
- English
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