Anhidrotic ectodermal dysplasia gene region cloned in yeast artificial chromosomes

Journal Article · Sat May 01 00:00:00 EDT 1993 · Genomics

DOI:https://doi.org/10.1006/geno.1993.1189· OSTI ID:28960

Kere, J ^[1]; Grzeschik, K H ^[2]; Limon, J ^[3]; Gremaud, M; Schlessinger, D ^[1]; De La Chapelle, A ^[4]

---

1. Washington Univ. School of Medicine, St. Louis, MO (United States)
2. Univ. of Marburg (Germany)
3. Medical Academy, Gdansk (Poland)
4. Univ. of Helsinki (Finland)

Anhidrotic ectodermal dysplasia (EDA), an X-chromosomal recessive disorder, is expressed in a few females with chromosomal translocations involving bands Xq12-q13. Using available DNA markers from the region and somatic cell hybrids the authors mapped the X-chromosomal breakpoints in two such translocations. The breakpoints were further mapped within a yeast artificial chromosome contig constructed by chromosome walking techniques. Genomic DNA markers that map between the two translocation breakpoints were recovered representing putative portions of the EDA gene. 32 refs., 3 figs., 1 tab.

• OSTI ID: 28960
• Journal Information: Genomics, Vol. 16, Issue 2; Other Information: PBD: May 1993
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
SKIN DISEASES
ETIOLOGY
HUMAN X CHROMOSOME
GENETIC MAPPING
DNA-CLONING
GENE MUTATIONS
CHROMOSOMAL ABERRATIONS
HEREDITARY DISEASES