Anhidrotic ectodermal dysplasia gene region cloned in yeast artificial chromosomes
- Washington Univ. School of Medicine, St. Louis, MO (United States)
- Univ. of Marburg (Germany)
- Medical Academy, Gdansk (Poland)
- Univ. of Helsinki (Finland)
Anhidrotic ectodermal dysplasia (EDA), an X-chromosomal recessive disorder, is expressed in a few females with chromosomal translocations involving bands Xq12-q13. Using available DNA markers from the region and somatic cell hybrids the authors mapped the X-chromosomal breakpoints in two such translocations. The breakpoints were further mapped within a yeast artificial chromosome contig constructed by chromosome walking techniques. Genomic DNA markers that map between the two translocation breakpoints were recovered representing putative portions of the EDA gene. 32 refs., 3 figs., 1 tab.
- OSTI ID:
- 28960
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 16; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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