Genetic mapping of the hereditary mixed polyposis syndrome to chromosome 6q
Journal Article
·
· American Journal of Human Genetics
OSTI ID:285059
- and others
Hereditary mixed polyposis syndrome (HMPS) is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. HMPS appears to be inherited in an autosomal dominant manner. Genetic linkage analysis has been performed on a large family with HMPS. Data did not support linkage to the APC locus or to any of the loci for hereditary nonpolyposis colorectal cancer. Evidence that the HMPS locus lies on chromosome 6q was, however, provided by significant two-point LOD scores for linkage between HMPS and the D6S283 locus. Analysis of recombinants and multipoint linkage analysis suggested that the HMPS locus lies in a 4-cM interval containing the D6S283 locus and flanked by markers D6S468 and D6S301. 10 refs., 4 figs., 1 tab.
- OSTI ID:
- 285059
- Journal Information:
- American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: 4 Vol. 58; ISSN AJHGAG; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
Similar Records
Exclusion mapping of a third HNPCC locus in a large Lynch I kindred
Exclusion of the APC gene as the cause of a variant form of familial adenomatous polyposis (FAP)
Hereditary nonpolyposis colon cancer: Analysis of linkage to 2p 15-16 places the COCA1 locus telomeric to D2S123 and reveals genetic heterogeneity in seven Canadian families
Journal Article
·
Thu Sep 01 00:00:00 EDT 1994
· American Journal of Human Genetics
·
OSTI ID:133542
Exclusion of the APC gene as the cause of a variant form of familial adenomatous polyposis (FAP)
Journal Article
·
Sun Oct 31 23:00:00 EST 1993
· American Journal of Human Genetics; (United States)
·
OSTI ID:5440007
Hereditary nonpolyposis colon cancer: Analysis of linkage to 2p 15-16 places the COCA1 locus telomeric to D2S123 and reveals genetic heterogeneity in seven Canadian families
Journal Article
·
Wed Jun 01 00:00:00 EDT 1994
· American Journal of Human Genetics; (United States)
·
OSTI ID:7159780