Cell cycle regulation of centromere function in Saccharomyces cerevisiae
- Univ. of North Carolina, Chapel Hill, NC (United States)
Accurate transmission of eukaryotic chromosomes is dependent on a specialized region of the chromosome, the centromere. The centromere is the site of assembly of the kinetochore, an integrated protein/DNA complex which acts as the point of attachment between individual chromosomes and the mitotic spindle. The presence of more than one centromere on a single chromosome (dicentric chromosome) is deleterious, resulting in broken chromosome derivatives and unstable chromosome inheritance. Dicentric chromosomes were first studied extensively in Zea mays. Cytogenetic observations of the mitotic behavior of these chromosomes illustrates a sequence of events termed a breakage-fusion-bridge cycle. When the two centromeres of a single chromosome are pulled to opposite poles during mitosis, the resulting anaphase bridge which forms between them is often broken. The broken ends are highly reactive, and by fusing with other chromsomes produce a number of chromosomal anomalies, including deletions, translocations, and the regeneration of dicentric chromosomes. This cycle persists until stable rearrangements are formed.
- OSTI ID:
- 28435
- Report Number(s):
- CONF-9210475-Cond.; TRN: 95:001845-0009
- Resource Relation:
- Conference: NATO advanced research workshop, Crete (Greece), 10-15 Oct 1992; Other Information: PBD: 1993; Related Information: Is Part Of Chromosome segregation and aneuploidy; Vig, B.K. [ed.] [University of Nevada, Reno, NV (United States). Dept. of Biology]; PB: 429 p.
- Country of Publication:
- United States
- Language:
- English
Similar Records
Centromere organization in man and mouse
Disruption of centromere function by 2-aminopurine