The cytological manifestation of gene amplification in multidrug-resistant mouse leukemia P388 sublines is correlated with amplicon content

Journal Article · Sun Oct 01 00:00:00 EDT 1995 · Russian Journal of Genetics

OSTI ID:283141

Il`inskaya, G V; Kopnin, B P ^[1]; Demidova, N S ^[2]

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1. Institute of Carcinogenesis, Moscow (Russian Federation)
2. Institute of Chemical Physics, Moscow (Russian Federation)

Previously, we showed that development of multidrug resistance (MDR) in mouse P388 leukemia cells is often associated with the appearance of newly-formed chromosomelike structures that contain amplified copies of the mdr1 gene. In the present study, we compared amplicon content in P388 sublines showing different types of these structures. A strong correlation between the formation of specific acentric markers consisting of two identical arms and the absence of the sorcin gene coamplification was found. In all the sublines containing other types of chromosomelike structures, the sorcin gene is coamplified. 9 refs., 2 figs., 1 tab.

• OSTI ID: 283141
• Journal Information: Russian Journal of Genetics, Vol. 31, Issue 10; Other Information: PBD: Oct 1995; TN: Translated from Genetika; 31: No. 10, 1449-1451(1995)
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
GENE AMPLIFICATION
MICE
LEUKEMIA
ANIMAL CELLS
MICROBIAL DRUG RESISTANCE
MITOSIS
CHROMOSOMES
BIOLOGICAL MARKERS