A new human IghV4.21-related pseudogene capable of VDJ rearrangement

Journal Article · Sun Sep 01 00:00:00 EDT 1996 · Immunogenetics

DOI:https://doi.org/10.1007/s002510050070· OSTI ID:273490

Dunn-Walters, D K; Isaacson, P J; Spencer, J ^[1]

---

1. U.C.L.M.S., London (United Kingdom)

The IghViv family has been reported to consist of 13 different genes, only one of which is a pseudogene. The IghViv family member IghV4.21 is widely used, and is known to encode immunoglobulin specific for the red blood cell antigens I and i in germline configuration. We have previously reported a rearranged IghV4.21 gene, isolated from the marginal zone of normal human spleen, which has two large deletions in FR1 and FR2/CDR2. We have now identified the same IghV gene sequence rearranged to a different diversity (D) region, in plasma cells of the intestinal lamina propria in a different patient, suggesting that this sequence represents a new IghViv family pseudogene related to IghV4.21. 6 refs., 1 fig.

• OSTI ID: 273490
• Journal Information: Immunogenetics, Vol. 43, Issue 5; Other Information: PBD: 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
STRUCTURE-ACTIVITY RELATIONSHIPS
GENE MUTATIONS
DNA SEQUENCING
DNA-CLONING
IMMUNOGLOBULINS
ANTIGENS
BLOOD CELLS
POLYMERASE CHAIN REACTION
PATIENTS