cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uK{sub ATP}-1, gene (KCNJ8)
- Chiba Univ. School of Medicine, Chiba (Japan)
- Kyoto Prefectural Univ. of Medicine (Japan)
ATP-sensitive K{sup +} (KATP) channels play a crucial role in coupling metabolic energy to the membrane potential of cells. Recently, we have isolated a KATP channel cDNA (uK{sub ATP}-1) that is expressed ubiquitously in rat tissues including pancreatic islets, pituitary, skeletal muscle, and heart. Here, we report cloning of the human cDNA and gene encoding uK{sub ATP}-1. Human uK{sub ATP}-1 is a protein of 424 amino acids exhibiting 98% identity with rat uK{sub ATP}-1. The human gene encoding uK{sub ATP}-1, designated KCNJ8, is approximately 9.7 kb in length and is composed of three exons. KCNJ8 was mapped to chromosome 12p11.23 using fluorescence in situ hybridization. 14 refs., 2 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 273462
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 30; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
Similar Records
cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes
Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2
Human gastric inhibitory polypeptide receptor: Cloning of the gene (GIPR) and cDNA
Journal Article
·
Sat Oct 31 23:00:00 EST 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6771309
Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2
Journal Article
·
Thu Aug 10 00:00:00 EDT 1995
· Genomics
·
OSTI ID:390669
Human gastric inhibitory polypeptide receptor: Cloning of the gene (GIPR) and cDNA
Journal Article
·
Tue Oct 10 00:00:00 EDT 1995
· Genomics
·
OSTI ID:443880