Cyclotron production of a 204Bi/204mPb generator by 24 MeV proton irradiation of natural Pb foil targets

Blanco, Jose R.; Edwards, Tracy S.; Irvin, Trenton E.; Kleinfeldt, Chloe R.; Lapi, Suzanne E.; Severin, Gregory W.

doi:10.1016/j.apradiso.2025.112147

Cyclotron production of a ²⁰⁴Bi/^204mPb generator by 24 MeV proton irradiation of natural Pb foil targets

Journal Article · Sat Aug 30 00:00:00 EDT 2025 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2025.112147· OSTI ID:2602259

Blanco, Jose R. ^[1]; Edwards, Tracy S. ^[1]; Irvin, Trenton E. ^[2]; Kleinfeldt, Chloe R. ^[1]; Lapi, Suzanne E. ^[2]; ^[1]

Michigan State University, East Lansing, MI (United States)
University of Alabama at Birmingham, AL (United States)

This work focuses on the formation of a generator of ²⁰⁴Bi/^204mPb for future applications in perturbed angular correlation spectroscopy and biological radiotracing with lead and bismuth isotopes. Generators were formed from the irradiation of natural Pb targets with 24 MeV protons producing ^{203,204,205,206,207}Bi that were rapidly dissolved in 3 M HNO₃ and 30 % H₂O₂ and exchanged into a 0.1 M HCl matrix. Use of 100 mg anion exchange resin (AG 1-x8) allowed ^203,204mPb to be eluted in 600 μL of 0.1 M HCl. Furthermore, the longer-lived ^205,206Bi were eluted in 5 mL or 3 mL of either 0.25 M sodium acetate buffer pH 4.4 or 1.0 M H₂SO₄. Initial radiolabeling was conducted with eluted ²⁰⁶Bi using DTPA and DOTA and ²⁰³Pb using TCMC-Azide.

View Accepted Manuscript (DOE)

Research Organization:: Michigan State University, East Lansing, MI (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0021220; SC0021269

OSTI ID:: 2602259

Journal Information:: Applied Radiation and Isotopes, Journal Name: Applied Radiation and Isotopes Vol. 226; ISSN 0969-8043

Publisher:: Elsevier BVCopyright Statement

Country of Publication:: United States

Language:: English

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