Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms

Journal Article · Wed Sep 20 04:00:00 EDT 1995 · Genomics

DOI:https://doi.org/10.1006/geno.1995.9995· OSTI ID:258272

Pham-Dinh, D; Gaspera, D B; Dautigny, A ^[1]

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1. Universite de Paris (France); and others

Myelin/oligodendrocyte glycoprotein (MOG), a special component of the central nervous system localization on the outermost lamellae of mature myelin, is a member of the immunoglobulin superfamily. We report here the organization of the human MOG gene, which spans approximately 17 kb, and the characterization of six MOG mRNA splicing variants. The intron/exon structure of the human MOG gene confirmed the splicing pattern, supporting the hypothesis that mRNA isoforms could arise by alternative splicing of a single gene. In addition to the eight exons coding for the major MOG isoform, the human MOG gene also contains 3` region, a previously unknown alternatively spliced coding exon, VIA. Alternative utilization of two acceptor splicing sites for exon VIII could produce two different C-termini. The nucleotide sequences presented here may be a useful tool to study further possible involvement if the MOG gene in hereditary neurological disorders. 23 refs., 5 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 258272
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 29; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
DNA SEQUENCING
EXONS
GENES
GLYCOPROTEINS
HEREDITARY DISEASES
IMMUNOGLOBULINS
INTRONS
MYELIN
NERVOUS SYSTEM DISEASES
NUCLEOTIDES
POLYMERASE CHAIN REACTION
SPLICING
STRUCTURE-ACTIVITY RELATIONSHIPS