Production and Purification of Terbium-155 Using Natural Gadolinium Targets

Pyles, Jennifer M.; Irvin, Trenton E.; Renne, Amy; Happel, Steffen; Nolen, Jerry; Lapi, Suzanne E.

doi:10.1021/acsomega.5c01653

Production and Purification of Terbium-155 Using Natural Gadolinium Targets

Journal Article · Tue Jul 08 00:00:00 EDT 2025 · ACS Omega

DOI:https://doi.org/10.1021/acsomega.5c01653· OSTI ID:2574006

^[1]; Irvin, Trenton E. ^[1]; Renne, Amy ^[2]; Happel, Steffen ^[3]; Nolen, Jerry ^[4]; ^[1]

University of Alabama at Birmingham, AL (United States)
Argonne National Laboratory (ANL), Argonne, IL (United States); University of Chicago, IL (United States)
TrisKem International, Bruz (France)
Argonne National Laboratory (ANL), Argonne, IL (United States)

Terbium-155 (t_1/2 = 5.32 days) is one of four medically relevant radioisotopes of terbium. It is of interest to the field as a suitable diagnostic counterpart for therapeutic radiolanthanides, as its decay scheme includes γ-rays that are suitable for single photon emission computed tomography (SPECT) imaging. Additionally, ¹⁵⁵Tb has an Auger electron (AE) yield that is viable for AE therapy. There are several direct and indirect production routes that can produce ¹⁵⁵Tb. Two possible direct routes include proton irradiation on gadolinium targets via ¹⁵⁵Gd(p,n) ¹⁵⁵Tb and ¹⁵⁶Gd(p,2n) ¹⁵⁵Tb. The ¹⁵⁵Gd(p,n) ¹⁵⁵Tb reaction is accessible at incident proton beam energies of ∼10 MeV, whereas the ¹⁵⁶Gd(p,2n) ¹⁵⁵Tb nuclear reaction requires ∼18 MeV. This study aims to investigate the production of ¹⁵⁵Tb from natGd through the ^natGd(p,x) nuclear reaction, wherein both (p,n) and (p,2n) reactions were leveraged, and the purification using a three-column ion chromatography method. Using this system, recoveries of radioterbium of up to 97% were achieved in addition to high recoveries of the Gd target material, illustrating the suitability of this technique for enriched targets.

View Accepted Manuscript (DOE)

Research Organization:: University of Alabama at Birmingham, AL (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-06CH11357; SC0021269

OSTI ID:: 2574006

Journal Information:: ACS Omega, Journal Name: ACS Omega Journal Issue: 28 Vol. 10; ISSN 2470-1343

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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