Quorum sensing modulates microbial community structure through regulation of secondary metabolites

Armes, April C.; Schaefer, Amy L.; Hochanadel, Leah H.; Klingeman, Dawn M.; Carper, Dana L.; Abraham, Paul E.; York, Larry M.; Carrell, Alyssa A.; Doktycz, Mitchel J.; Pelletier, Dale A.

doi:10.1128/msphere.01050-24

Quorum sensing modulates microbial community structure through regulation of secondary metabolites

Journal Article · Fri Jun 20 00:00:00 EDT 2025 · mSphere

DOI:https://doi.org/10.1128/msphere.01050-24· OSTI ID:2573449

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Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Univ. of Washington, Seattle, WA (United States)

Bacteria are recognized for their diverse metabolic capabilities, yet the impact of microbe-microbe interactions on multispecies community structure and dynamics is poorly understood. Cell-to-cell signaling in the form of quorum sensing (QS) often regulates secondary metabolite production and microbial interactions. Here, we examine how acylhomoserine lactone (AHL)-mediated QS impacts microbial community structure in a 10-member synthetic community of isolates from Populus deltoides. To explore the role of QS in microbial community structure and dynamics, we disrupted AHL signaling by exogenous addition of AiiA-lactonase, an enzyme that cleaves the lactone ring. Microbial community structure resulting from signal inactivation, as measured by 16S rRNA amplicon sequencing and secondary metabolite production, was assessed after successive passaging of the community. Further, we investigated the impact of quorum quenching on specific microbe-microbe interactions using pairwise inhibition assays. Our results indicate that AHL inactivation alters the relative abundance of dominant community members at later passages but does not impact the overall membership in the community. Quorum quenching significantly alters the metabolic profile in lactonase-treated communities. This metabolic alteration impacts microbe-microbe interactions through decreased inhibition of other community members. Together, these results indicate that QS impacts microbial community structure through the regulation of secondary metabolites in dominant members and that the membership of microbial communities can be relatively stable despite changes in metabolic profiles.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 2573449

Journal Information:: mSphere, Journal Name: mSphere Journal Issue: 7 Vol. 10; ISSN 2379-5042

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

References (81)

“Hot Stuff”: The Many Uses of a Radiolabel Assay in Detecting Acyl-Homoserine Lactone Quorum-Sensing Signals Schaefer, Amy L.; Harwood, Caroline S.; Greenberg, E. Peter Methods in Molecular Biology https://doi.org/10.1007/978-1-4939-7309-5_3	book	November 2017
Quorum Sensing and Phenazines are Involved in Biofilm Formation by Pseudomonas chlororaphis (aureofaciens) Strain 30-84 Maddula, V. S. R. K.; Zhang, Z.; Pierson, E. A. Microbial Ecology, Vol. 52, Issue 2 https://doi.org/10.1007/s00248-006-9064-6	journal	August 2006
Metabolomic analysis of quorum sensing inhibitor hordenine on Pseudomonas aeruginosa Zhou, Jin-Wei; Muhammad, Junaid; Sun, Bing Applied Microbiology and Biotechnology, Vol. 103, Issue 15 https://doi.org/10.1007/s00253-019-09878-w	journal	June 2019
Bacillus Co-culture Inhibits Quorum Sensing in Pseudomonas aeruginosa Jiang, Bo; Wu, Chunyan; Liang, Yuan Current Microbiology, Vol. 80, Issue 4 https://doi.org/10.1007/s00284-023-03218-y	journal	March 2023
Proposed minimum reporting standards for chemical analysis: Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI) Sumner, Lloyd W.; Amberg, Alexander; Barrett, Dave Metabolomics, Vol. 3, Issue 3 https://doi.org/10.1007/s11306-007-0082-2	journal	September 2007
Bacterial-fungal interactions under agricultural settings: from physical to chemical interactions Zhou, Yaqi; Wang, Hongkai; Xu, Sunde Stress Biology, Vol. 2, Issue 1 https://doi.org/10.1007/s44154-022-00046-1	journal	June 2022
Biocontrol ability of phenazine-producing strains for the management of fungal plant pathogens: A review Wang, Su-Yan; Shi, Xin-Chi; Chen, Xin Biological Control, Vol. 155 https://doi.org/10.1016/j.biocontrol.2021.104548	journal	April 2021
Formation, characterization and modeling of emergent synthetic microbial communities Wang, Jia; Carper, Dana L.; Burdick, Leah H. Computational and Structural Biotechnology Journal, Vol. 19 https://doi.org/10.1016/j.csbj.2021.03.034	journal	January 2021
Competition, Not Cooperation, Dominates Interactions among Culturable Microbial Species Foster, Kevin R.; Bell, Thomas Current Biology, Vol. 22, Issue 19 https://doi.org/10.1016/j.cub.2012.08.005	journal	October 2012
Keystone metabolites of crop rhizosphere microbiomes Dahlstrom, Kurt M.; McRose, Darcy L.; Newman, Dianne K. Current Biology, Vol. 30, Issue 19 https://doi.org/10.1016/j.cub.2020.08.005	journal	October 2020
Trophic Interactions and the Drivers of Microbial Community Assembly Gralka, Matti; Szabo, Rachel; Stocker, Roman Current Biology, Vol. 30, Issue 19 https://doi.org/10.1016/j.cub.2020.08.007	journal	October 2020
Applying molecular and phenotypic screening assays to identify efficient quorum quenching lactonases Billot, Raphaël; Plener, Laure; Grizard, Damien Enzyme and Microbial Technology, Vol. 160 https://doi.org/10.1016/j.enzmictec.2022.110092	journal	October 2022
Phaeobacter inhibens as biocontrol agent against Vibrio vulnificus in oyster models Porsby, Cisse Hedegaard; Gram, Lone Food Microbiology, Vol. 57 https://doi.org/10.1016/j.fm.2016.01.005	journal	August 2016
Changes in respiration activities and bacterial communities in a bioaugmented oil-polluted soil in response to the addition of acyl homoserine lactones Al-Kharusi, Samiha; Abed, Raeid M. M.; Dobretsov, Sergey International Biodeterioration & Biodegradation, Vol. 107 https://doi.org/10.1016/j.ibiod.2015.11.021	journal	February 2016
Regulation of phenazine-1-carboxamide production by quorum sensing in type strains of Pseudomonas chlororaphis subsp. chlororaphis and Pseudomonas chlororaphis subsp. piscium Morohoshi, Tomohiro; Yabe, Naoka; Yaguchi, Naoya Journal of Bioscience and Bioengineering, Vol. 133, Issue 6 https://doi.org/10.1016/j.jbiosc.2022.03.004	journal	June 2022
Exogenous acyl-homoserine lactones adjust community structures of bacteria and methanogens to ameliorate the performance of anaerobic granular sludge Lv, Longyi; Li, Weiguang; Zheng, Zejia Journal of Hazardous Materials, Vol. 354 https://doi.org/10.1016/j.jhazmat.2018.04.075	journal	July 2018
Macroencapsulation of quorum quenching bacteria by polymeric membrane layer and its application to MBR for biofouling control Kim, Sang-Ryoung; Lee, Ki-Baek; Kim, Jeong-Eun Journal of Membrane Science, Vol. 473 https://doi.org/10.1016/j.memsci.2014.09.009	journal	January 2015
Quorum quenching activity of AiiA lactonase KMMI17 from endophytic Bacillus thuringiensis KMCL07 on AHL- mediated pathogenic phenotype in Pseudomonas aeruginosa Anandan, Kanmani; Vittal, Ravishankar Rai Microbial Pathogenesis, Vol. 132 https://doi.org/10.1016/j.micpath.2019.05.015	journal	July 2019
Burkholderia cepacia YtnP and Y2-aiiA lactonases inhibit virulence of Pseudomonas aeruginosa via quorum quenching activity Malešević, Milka; Stanisavljević, Nemanja; Novović, Katarina Microbial Pathogenesis, Vol. 149 https://doi.org/10.1016/j.micpath.2020.104561	journal	December 2020
AHL-mediated quorum sensing to regulate bacterial substance and energy metabolism: A review Liu, Lanlan; Zeng, Xiangyong; Zheng, Jia Microbiological Research, Vol. 262 https://doi.org/10.1016/j.micres.2022.127102	journal	September 2022
Quorum sensing-mediated microbial interactions: Mechanisms, applications, challenges and perspectives Zeng, Xiangyong; Zou, Yunman; Zheng, Jia Microbiological Research, Vol. 273 https://doi.org/10.1016/j.micres.2023.127414	journal	August 2023
Bacillus quorum quenching shapes the citrus mycobiome through interkingdom signaling Ahmed, Ayesha; Liu, Yinglong; He, Pengbo Science of The Total Environment, Vol. 956 https://doi.org/10.1016/j.scitotenv.2024.177074	journal	December 2024
Metabolomics Uncovers the Regulatory Pathway of Acyl-homoserine Lactones Based Quorum Sensing in Anammox Consortia Tang, Xi; Guo, Yongzhao; Wu, Shanshan Environmental Science & Technology, Vol. 52, Issue 4 https://doi.org/10.1021/acs.est.7b05699	journal	February 2018
Structural Basis of Acyl-homoserine Lactone-Dependent Signaling Churchill, Mair E. A.; Chen, Lingling Chemical Reviews, Vol. 111, Issue 1 https://doi.org/10.1021/cr1000817	journal	December 2010
Control of Membrane Biofouling in MBR for Wastewater Treatment by Quorum Quenching Bacteria Encapsulated in Microporous Membrane Oh, Hyun-Suk; Yeon, Kyung-Min; Yang, Cheon-Seok Environmental Science & Technology, Vol. 46, Issue 9 https://doi.org/10.1021/es204312u	journal	April 2012
Identifying Small Molecules via High Resolution Mass Spectrometry: Communicating Confidence Schymanski, Emma L.; Jeon, Junho; Gulde, Rebekka Environmental Science & Technology, Vol. 48, Issue 4 https://doi.org/10.1021/es5002105	journal	February 2014
Acyl-homoserine lactone-dependent eavesdropping promotes competition in a laboratory co-culture model Chandler, Josephine R.; Heilmann, Silja; Mittler, John E. The ISME Journal, Vol. 6, Issue 12 https://doi.org/10.1038/ismej.2012.69	journal	July 2012
A synthetic multicellular system for programmed pattern formation Basu, Subhayu; Gerchman, Yoram; Collins, Cynthia H. Nature, Vol. 434, Issue 7037 https://doi.org/10.1038/nature03461	journal	April 2005
NIH Image to ImageJ: 25 years of image analysis Schneider, Caroline A.; Rasband, Wayne S.; Eliceiri, Kevin W. Nature Methods, Vol. 9, Issue 7 https://doi.org/10.1038/nmeth.2089	journal	June 2012
Listening in on bacteria: acyl-homoserine lactone signalling Fuqua, Clay; Greenberg, E. Peter Nature Reviews Molecular Cell Biology, Vol. 3, Issue 9 https://doi.org/10.1038/nrm907	journal	September 2002
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 Bolyen, Evan; Rideout, Jai Ram; Dillon, Matthew R. Nature Biotechnology, Vol. 37, Issue 8 https://doi.org/10.1038/s41587-019-0209-9	journal	July 2019
Genomic features of bacterial adaptation to plants Levy, Asaf; Salas Gonzalez, Isai; Mittelviefhaus, Maximilian Nature Genetics, Vol. 50, Issue 1 https://doi.org/10.1038/s41588-017-0012-9	journal	December 2017
Dimension-reduction simplifies the analysis of signal crosstalk in a bacterial quorum sensing pathway Miller, Taylor; Patel, Keval; Rodriguez, Coralis Scientific Reports, Vol. 11, Issue 1 https://doi.org/10.1038/s41598-021-99169-0	journal	October 2021
Potential roles of acyl homoserine lactones (AHLs) in nitrifying bacteria survival under certain adverse circumstances Zeng, Xiangguo; Hu, Huizhi Scientific Reports, Vol. 13, Issue 1 https://doi.org/10.1038/s41598-022-23123-x	journal	February 2023
Quorum sensing and motility mediate interactions between Pseudomonas aeruginosa and Agrobacterium tumefaciens in biofilm cocultures An, D.; Danhorn, T.; Fuqua, C. Proceedings of the National Academy of Sciences, Vol. 103, Issue 10 https://doi.org/10.1073/pnas.0511323103	journal	February 2006
Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium Brenner, K.; Karig, D. K.; Weiss, R. Proceedings of the National Academy of Sciences, Vol. 104, Issue 44 https://doi.org/10.1073/pnas.0704256104	journal	October 2007
Cofunctioning of bacterial exometabolites drives root microbiota establishment Getzke, Felix; Hassani, M. Amine; Crüsemann, Max Proceedings of the National Academy of Sciences, Vol. 120, Issue 15 https://doi.org/10.1073/pnas.2221508120	journal	April 2023
A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism Cao, Hui; Krishnan, Gomathi; Goumnerov, Boyan Proceedings of the National Academy of Sciences, Vol. 98, Issue 25 https://doi.org/10.1073/pnas.251465298	journal	November 2001
Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations with higher organisms Parsek, M. R.; Greenberg, E. P. Proceedings of the National Academy of Sciences, Vol. 97, Issue 16 https://doi.org/10.1073/pnas.97.16.8789	journal	August 2000
Mechanisms of Succession in Natural Communities and Their Role in Community Stability and Organization Connell, Joseph H.; Slatyer, Ralph O. The American Naturalist, Vol. 111, Issue 982 https://doi.org/10.1086/283241	journal	November 1977
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments MacLean, Brendan; Tomazela, Daniela M.; Shulman, Nicholas Bioinformatics, Vol. 26, Issue 7 https://doi.org/10.1093/bioinformatics/btq054	journal	February 2010
Genetic and functional diversity of PsyI/PsyR quorum-sensing system in the Pseudomonas syringae complex Morohoshi, Tomohiro; Oshima, Akinori; Xie, Xiaonan FEMS Microbiology Ecology, Vol. 97, Issue 2 https://doi.org/10.1093/femsec/fiaa254	journal	December 2020
Intensive field phenotyping of maize ( Zea mays L.) root crowns identifies phenes and phene integration associated with plant growth and nitrogen acquisition York, Larry M.; Lynch, Jonathan P. Journal of Experimental Botany, Vol. 66, Issue 18 https://doi.org/10.1093/jxb/erv241	journal	June 2015
Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides Wynendaele, Evelien; Bronselaer, Antoon; Nielandt, Joachim Nucleic Acids Research, Vol. 41, Issue D1 https://doi.org/10.1093/nar/gks1137	journal	November 2012
SigMol: repertoire of quorum sensing signaling molecules in prokaryotes Rajput, Akanksha; Kaur, Karambir; Kumar, Manoj Nucleic Acids Research, Vol. 44, Issue D1 https://doi.org/10.1093/nar/gkv1076	journal	October 2015
Look who's talking: communication and quorum sensing in the bacterial world Williams, Paul; Winzer, Klaus; Chan, Weng C. Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 362, Issue 1483 https://doi.org/10.1098/rstb.2007.2039	journal	March 2007
N-Acylhomoserine lactone quorum-sensing signalling in antagonistic phenazine-producing Pseudomonas isolates from the red cocoyam rhizosphere De Maeyer, K.; D'aes, J.; Hua, G. K. H. Microbiology, Vol. 157, Issue 2 https://doi.org/10.1099/mic.0.043125-0	journal	February 2011
N ‐acyl‐ l ‐homoserine lactones (AHLs) affect microbial community composition and function in activated sludge Valle, Anna; Bailey, Mark J.; Whiteley, Andrew S. Environmental Microbiology, Vol. 6, Issue 4 https://doi.org/10.1111/j.1462-2920.2004.00581.x	journal	February 2004
Quorum-sensing autoinducer molecules produced by members of a multispecies biofilm promote horizontal gene transfer to Vibrio cholerae Antonova, Elena S.; Hammer, Brian K. FEMS Microbiology Letters, Vol. 322, Issue 1 https://doi.org/10.1111/j.1574-6968.2011.02328.x	journal	June 2011
Emergent simplicity in microbial community assembly Goldford, Joshua E.; Lu, Nanxi; Bajić, Djordje Science, Vol. 361, Issue 6401 https://doi.org/10.1126/science.aat1168	journal	August 2018
Maximizing Growth Yield and Dispersal via Quorum Sensing Promotes Cooperation in Vibrio Bacteria Bruger, Eric L.; Waters, Christopher M. Applied and Environmental Microbiology, Vol. 84, Issue 14 https://doi.org/10.1128/AEM.00402-18	journal	July 2018
VqsA, a Novel LysR-Type Transcriptional Regulator, Coordinates Quorum Sensing (QS) and Is Controlled by QS To Regulate Virulence in the Pathogen Vibrio alginolyticus Gao, Xiating; Wang, Xuetong; Mao, Qiaoqiao Applied and Environmental Microbiology, Vol. 84, Issue 12 https://doi.org/10.1128/AEM.00444-18	journal	June 2018
LuxR- and LuxI-Type Quorum-Sensing Circuits Are Prevalent in Members of the Populus deltoides Microbiome Schaefer, Amy L.; Lappala, Colin R.; Morlen, Ryan P. Applied and Environmental Microbiology, Vol. 79, Issue 18 https://doi.org/10.1128/AEM.01417-13	journal	July 2013
Role of Quorum Sensing and Antimicrobial Component Production by Serratia plymuthica in Formation of Biofilms, Including Mixed Biofilms with Escherichia coli Moons, Pieter; Van Houdt, Rob; Aertsen, Abram Applied and Environmental Microbiology, Vol. 72, Issue 11 https://doi.org/10.1128/AEM.01708-06	journal	November 2006
Enhanced Biofilm Formation and Increased Resistance to Antimicrobial Agents and Bacterial Invasion Are Caused by Synergistic Interactions in Multispecies Biofilms Burmolle, M.; Webb, J. S.; Rao, D. Applied and Environmental Microbiology, Vol. 72, Issue 6 https://doi.org/10.1128/AEM.03022-05	journal	June 2006
Distinct Microbial Communities within the Endosphere and Rhizosphere of Populus deltoides Roots across Contrasting Soil Types Gottel, Neil R.; Castro, Hector F.; Kerley, Marilyn Applied and Environmental Microbiology, Vol. 77, Issue 17 https://doi.org/10.1128/AEM.05255-11	journal	July 2011
Agrobacterium Bioassay Strain for Ultrasensitive Detection of N-Acylhomoserine Lactone-Type Quorum-Sensing Molecules: Detection of Autoinducers in Mesorhizobium huakuii Zhu, Jun; Chai, Yunrong; Zhong, Zengtao Applied and Environmental Microbiology, Vol. 69, Issue 11 https://doi.org/10.1128/AEM.69.11.6949-6953.2003	journal	November 2003
Quorum Sensing Protects Pseudomonas aeruginosa against Cheating by Other Species in a Laboratory Coculture Model Smalley, Nicole E.; An, Dingding; Parsek, Matthew R. Journal of Bacteriology, Vol. 197, Issue 19 https://doi.org/10.1128/JB.00482-15	journal	October 2015
Twenty-One Genome Sequences from Pseudomonas Species and 19 Genome Sequences from Diverse Bacteria Isolated from the Rhizosphere and Endosphere of Populus deltoides Brown, S. D.; Utturkar, S. M.; Klingeman, D. M. Journal of Bacteriology, Vol. 194, Issue 21 https://doi.org/10.1128/JB.01243-12	journal	October 2012
Analogs of the Autoinducer 3-Oxooctanoyl-Homoserine Lactone Strongly Inhibit Activity of the TraR Protein of Agrobacterium tumefaciens Zhu, Jun; Beaber, John W.; Moré, Margret I. Journal of Bacteriology, Vol. 180, Issue 20 https://doi.org/10.1128/JB.180.20.5398-5405.1998	journal	October 1998
Culture Medium for Enterobacteria Neidhardt, Frederick C.; Bloch, Philip L.; Smith, David F. Journal of Bacteriology, Vol. 119, Issue 3 https://doi.org/10.1128/jb.119.3.736-747.1974	journal	January 1974
Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues? Stabb, Eric V. mBio, Vol. 9, Issue 3 https://doi.org/10.1128/mBio.00098-18	journal	July 2018
Positive Autoregulation of an Acyl-Homoserine Lactone Quorum-Sensing Circuit Synchronizes the Population Response Scholz, Rebecca L.; Greenberg, E. Peter mBio, Vol. 8, Issue 4 https://doi.org/10.1128/mBio.01079-17	journal	September 2017
luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria Brotherton, Carolyn A.; Medema, Marnix H.; Greenberg, E. Peter mSystems, Vol. 3, Issue 3 https://doi.org/10.1128/mSystems.00208-17	journal	March 2018
Evolution of the Quorum Sensing Regulon in Cooperating Populations of Pseudomonas aeruginosa Smalley, Nicole E.; Schaefer, Amy L.; Asfahl, Kyle L. mBio, Vol. 13, Issue 1 https://doi.org/10.1128/mbio.00161-22	journal	February 2022
Formation of a constructed microbial community in a nutrient-rich environment indicates bacterial interspecific competition Wang, Jia; Appidi, Manasa R.; Burdick, Leah H. mSystems, Vol. 9, Issue 4 https://doi.org/10.1128/msystems.00006-24	journal	April 2024
Decoding the chemical language of Suillus fungi: genome mining and untargeted metabolomics uncover terpene chemical diversity Mudbhari, Sameer; Lofgren, Lotus; Appidi, Manasa R. mSystems https://doi.org/10.1128/msystems.01225-23	journal	March 2024
Cultivating the Bacterial Microbiota of Populus Roots Carper, Dana L.; Weston, David J.; Barde, Aditya mSystems, Vol. 6, Issue 3 https://doi.org/10.1128/msystems.01306-20	journal	June 2021
Quorum Sensing and Antimicrobial Production Orchestrate Biofilm Dynamics in Multispecies Bacterial Communities Armes, April C.; Walton, Jillian L.; Buchan, Alison Microbiology Spectrum, Vol. 10, Issue 6 https://doi.org/10.1128/spectrum.02615-22	journal	December 2022
Regulation of Gene Expression by Cell-to-Cell Communication: Acyl-Homoserine Lactone Quorum Sensing Fuqua, Clay; Parsek, Matthew R.; Greenberg, E. Peter Annual Review of Genetics, Vol. 35, Issue 1 https://doi.org/10.1146/annurev.genet.35.102401.090913	journal	December 2001
The Populus holobiont: dissecting the effects of plant niches and genotype on the microbiome Cregger, M. A.; Veach, A. M.; Yang, Z. K. Microbiome, Vol. 6, Issue 1 https://doi.org/10.1186/s40168-018-0413-8	journal	February 2018
Evaluation of biological and enzymatic quorum quencher coating additives to reduce biocorrosion of steel Huang, Siqian; Bergonzi, Celine; Schwab, Michael PLOS ONE, Vol. 14, Issue 5 https://doi.org/10.1371/journal.pone.0217059	journal	May 2019
Cutadapt removes adapter sequences from high-throughput sequencing reads Martin, Marcel EMBnet.journal, Vol. 17, Issue 1 https://doi.org/10.14806/ej.17.1.200	journal	May 2011
Cyclic di-GMP Is Integrated Into a Hierarchal Quorum Sensing Network Regulating Antimicrobial Production and Biofilm Formation in Roseobacter Clade Member Rhodobacterales Strain Y4I Armes, April C.; Buchan, Alison Frontiers in Marine Science, Vol. 8 https://doi.org/10.3389/fmars.2021.681551	journal	July 2021
Effect of Quorum Quenching Lactonase in Clinical Isolates of Pseudomonas aeruginosa and Comparison with Quorum Sensing Inhibitors Guendouze, Assia; Plener, Laure; Bzdrenga, Janek Frontiers in Microbiology, Vol. 08 https://doi.org/10.3389/fmicb.2017.00227	journal	February 2017
Signal Disruption Leads to Changes in Bacterial Community Population Schwab, Michael; Bergonzi, Celine; Sakkos, Jonathan Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.00611	journal	March 2019
Effects of Signal Disruption Depends on the Substrate Preference of the Lactonase Mahan, Kathleen; Martinmaki, Ryan; Larus, Isabel Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.03003	journal	January 2020
Lactonase Specificity Is Key to Quorum Quenching in Pseudomonas aeruginosa Rémy, Benjamin; Plener, Laure; Decloquement, Philippe Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.00762	journal	April 2020
Novel Quorum Quenching YtnP Lactonase From Bacillus paralicheniformis Reduces Pseudomonas aeruginosa Virulence and Increases Antibiotic Efficacy in vivo Djokic, Lidija; Stankovic, Nada; Galic, Ivana Frontiers in Microbiology, Vol. 13 https://doi.org/10.3389/fmicb.2022.906312	journal	June 2022
Phenazine-1-carboxylic Acid Produced by Pseudomonas chlororaphis YL-1 Is Effective against Acidovorax citrulli Liu, Youzhou; Zhou, Yaqiu; Qiao, Junqing Microorganisms, Vol. 9, Issue 10 https://doi.org/10.3390/microorganisms9102012	journal	September 2021
Secondary metabolites of Bacillus subtilis impact the assembly of soil-derived semisynthetic bacterial communities Kiesewalter, Heiko T.; Lozano-Andrade, Carlos N.; Strube, Mikael L. Beilstein Journal of Organic Chemistry, Vol. 16 https://doi.org/10.3762/bjoc.16.248	journal	December 2020

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59 BASIC BIOLOGICAL SCIENCES
AHLs
RAMs
SynComs
lactonase
microbial communities
phenazine
polymicrobial
quorum quenching
quorum sensing

Quorum sensing modulates microbial community structure through regulation of secondary metabolites

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References (81)

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