Aqueous Self‐Assembly of Cylindrical and Tapered Bottlebrush Block Copolymers

Vu, Clark; Abu Amara, Narjess; Alaboalirat, Mohammed; Nativ‐Roth, Einat; Zalk, Ran; Leite, Wellington; Carrillo, Jan‐Michael; Bitton, Ronit; Matson, John B.

doi:10.1002/anie.202500771

Aqueous Self‐Assembly of Cylindrical and Tapered Bottlebrush Block Copolymers

Journal Article · Fri Apr 25 00:00:00 EDT 2025 · Angewandte Chemie (International Edition)

DOI:https://doi.org/10.1002/anie.202500771· OSTI ID:2573251

Vu, Clark ^[1]; Abu Amara, Narjess ^[2]; Alaboalirat, Mohammed ^[1]; Nativ‐Roth, Einat ^[2]; Zalk, Ran ^[2]; ^[3]; ^[4]; Bitton, Ronit ^[2]; Matson, John B. ^[1]

Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)
Ben Gurion Univ. of the Negev, Beer Sheva (Israel)
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

The self‐assembly of amphiphilic bottlebrush block copolymers (BCPs), featuring backbones densely grafted with two types of side chains, is less well understood compared to linear BCPs. In particular, the solution self‐assembly of tapered bottlebrush BCPs—cone‐shaped BCPs with hydrophilic or hydrophobic tips—remains unexplored. This study investigates eight tapered and four cylindrical bottlebrush BCPs with varied ratios of hydrophobic polystyrene (PS) and hydrophilic poly(acrylic acid) (PAA) side chains, synthesized via sequential addition of macromonomers using ring‐opening metathesis polymerization (SAM‐ROMP). Self‐assembled nanostructures formed in water were analyzed using cryogenic transmission electron microscopy, small‐angle neutron scattering, and dynamic light scattering. Most BCPs generated multiple nanostructures with surface protrusions, including spherical micelles, cylindrical micelles, and vesicles, alongside transitional forms like ellipsoids and semi‐vesicles. Coarse‐grained molecular dynamics simulations supported the experimental findings, which revealed two distinct self‐assembly pathways. The first involved micelle fusion, producing elliptical and cylindrical aggregates, sometimes forming Y‐junctions. The second pathway featured micelle maturation into semivesicles, which developed into vesicles or large compound vesicles. This work provides the first experimental evidence of vesicle formation via semivesicles in bottlebrush BCPs and demonstrates the significant influence of cone directionality on self‐assembly behavior in these cone‐shaped polymeric amphiphiles.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 2573251

Journal Information:: Angewandte Chemie (International Edition), Journal Name: Angewandte Chemie (International Edition) Journal Issue: 23 Vol. 64; ISSN 1521-3773; ISSN 1433-7851

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

References (75)

Sequence-Mandated, Distinct Assembly of Giant Molecules Zhang, Wei; Lu, Xinlin; Mao, Jialin Angewandte Chemie International Edition, Vol. 56, Issue 47 https://doi.org/10.1002/anie.201709354	journal	October 2017
Self‐Assembly of Rod‐Coil Bottlebrush Copolymers into Degradable Nanodiscs with a UV‐Triggered Self‐Immolation Process Zeng, Haoxiang; Liang, Xiaoli; Roberts, Derrick A. Angewandte Chemie International Edition, Vol. 63, Issue 13 https://doi.org/10.1002/anie.202318881	journal	February 2024
Block copolymer solution self‐assembly: Recent advances, emerging trends, and applications Karayianni, Maria; Pispas, Stergios Journal of Polymer Science, Vol. 59, Issue 17 https://doi.org/10.1002/pol.20210430	journal	July 2021
Evaluation of critical packing parameter in the series of polytyrosine-PEG amphiphilic copolymers Iakimov, Nikolai P.; Zotkin, Maxim A.; Dets, Elizabeth A. Colloid and Polymer Science, Vol. 299, Issue 10 https://doi.org/10.1007/s00396-021-04853-2	journal	August 2021
The effects of polymeric nanostructure shape on drug delivery Venkataraman, Shrinivas; Hedrick, James L.; Ong, Zhan Yuin Advanced Drug Delivery Reviews, Vol. 63, Issue 14-15 https://doi.org/10.1016/j.addr.2011.06.016	journal	November 2011
A review of computational studies of bottlebrush polymers Mohammadi, Esmat; Joshi, Soumil Y.; Deshmukh, Sanket A. Computational Materials Science, Vol. 199 https://doi.org/10.1016/j.commatsci.2021.110720	journal	November 2021
Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes Contini, Claudia; Pearson, Russell; Wang, Linge iScience, Vol. 7 https://doi.org/10.1016/j.isci.2018.08.018	journal	September 2018
Colloid-like solution behavior of computationally designed coiled coil bundlemers Sinha, Nairiti J.; Guo, Rui; Misra, Rajkumar Journal of Colloid and Interface Science, Vol. 606 https://doi.org/10.1016/j.jcis.2021.09.184	journal	January 2022
Impact of mechanism of formation on encapsulation in block copolymer vesicles Adams, Dave J.; Adams, Sarah; Atkins, Derek Journal of Controlled Release, Vol. 128, Issue 2 https://doi.org/10.1016/j.jconrel.2008.03.006	journal	June 2008
Coil-to-rod conformational transition and single chain structure of graft copolymer by tuning the graft density Liu, Wenyong; Liu, Yuejun; Zeng, Guangsheng Polymer, Vol. 53, Issue 4 https://doi.org/10.1016/j.polymer.2012.01.006	journal	February 2012
Emerging trends in solution self-assembly of block copolymers Deng, Zhengyu; Liu, Shiyong Polymer, Vol. 207 https://doi.org/10.1016/j.polymer.2020.122914	journal	October 2020
Linear and non-linear triblock terpolymers. Synthesis, self-assembly in selective solvents and in bulk Hadjichristidis, N.; Iatrou, H.; Pitsikalis, M. Progress in Polymer Science, Vol. 30, Issue 7 https://doi.org/10.1016/j.progpolymsci.2005.04.001	journal	July 2005
Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications Iqbal, Shoaib; Blenner, Mark; Alexander-Bryant, Angela Biomacromolecules, Vol. 21, Issue 4 https://doi.org/10.1021/acs.biomac.9b01754	journal	February 2020
Effect of Molecular Architecture on the Self-Assembly of Bottlebrush Copolymers Gadelrab, Karim R.; Alexander-Katz, Alfredo The Journal of Physical Chemistry B, Vol. 124, Issue 50 https://doi.org/10.1021/acs.jpcb.0c07941	journal	December 2020
Synthesis of Cone-Shaped Colloids from Rod-Like Silica Colloids with a Gradient in the Etching Rate Hagemans, Fabian; van der Wee, Ernest B.; van Blaaderen, Alfons Langmuir, Vol. 32, Issue 16 https://doi.org/10.1021/acs.langmuir.6b00678	journal	April 2016
Synthesis and Aqueous Self-Assembly of ABCD Bottlebrush Block Copolymers Ahmed, Eman; Womble, C. Tyler; Weck, Marcus Macromolecules, Vol. 53, Issue 20 https://doi.org/10.1021/acs.macromol.0c01785	journal	October 2020
Implicit Side-Chain Model and Experimental Characterization of Bottlebrush Block Copolymer Solution Assembly Pan, Tianyuan; Patel, Bijal B.; Walsh, Dylan J. Macromolecules, Vol. 54, Issue 8 https://doi.org/10.1021/acs.macromol.1c00336	journal	April 2021
Solvent Effects in Grafting-through Ring-Opening Metathesis Polymerization Blosch, Sarah E.; Alaboalirat, Mohammed; Eades, Cabell B. Macromolecules, Vol. 55, Issue 9 https://doi.org/10.1021/acs.macromol.2c00254	journal	April 2022
Phase Behavior of Linear-Bottlebrush Block Polymers Liberman, Lucy; Coughlin, McKenzie L.; Weigand, Steven Macromolecules, Vol. 55, Issue 7 https://doi.org/10.1021/acs.macromol.2c00337	journal	March 2022
Complex Polymer Architectures Using Ring-Opening Metathesis Polymerization: Synthesis, Applications, and Practical Considerations Blosch, Sarah E.; Scannelli, Samantha J.; Alaboalirat, Mohammed Macromolecules, Vol. 55, Issue 11 https://doi.org/10.1021/acs.macromol.2c00338	journal	May 2022
Impact of Side-Chain Length on the Self-Assembly of Linear-Bottlebrush Diblock Copolymers Liberman, Lucy; Coughlin, McKenzie L.; Weigand, Steven Macromolecules, Vol. 55, Issue 12 https://doi.org/10.1021/acs.macromol.2c00758	journal	June 2022
Influence of the Norbornene Anchor Group in Ru-Mediated Ring-Opening Metathesis Polymerization: Synthesis of Linear Polymers Scannelli, Samantha J.; Paripati, Anshul; Weaver, Jeffrey R. Macromolecules, Vol. 56, Issue 11 https://doi.org/10.1021/acs.macromol.3c00172	journal	May 2023
Influence of the Norbornene Anchor Group in Ru-Mediated Ring-Opening Metathesis Polymerization: Synthesis of Bottlebrush Polymers Scannelli, Samantha J.; Alaboalirat, Mohammed; Troya, Diego Macromolecules, Vol. 56, Issue 11 https://doi.org/10.1021/acs.macromol.3c00214	journal	May 2023
Solution Structure and Scaling Laws of Cylindrical and Tapered Bottlebrush Polymers Alaboalirat, Mohammed; Scannelli, Samantha J.; Rahmaninejad, Hadi Macromolecules, Vol. 56, Issue 22 https://doi.org/10.1021/acs.macromol.3c01412	journal	November 2023
Scaling Behavior of Solution Self-Assembled Micelle of Sequence-Controlled Bottlebrush Copolymer Kwon, Sangwoo; Nam, Jiyun; Chung, Jae Wan Macromolecules, Vol. 57, Issue 15 https://doi.org/10.1021/acs.macromol.4c00226	journal	July 2024
Linear Rheology of Polyolefin-Based Bottlebrush Polymers Dalsin, Samuel J.; Hillmyer, Marc A.; Bates, Frank S. Macromolecules, Vol. 48, Issue 13 https://doi.org/10.1021/acs.macromol.5b01153	journal	June 2015
Interplay between Molecular Packing, Drug Loading, and Core Cross-Linking in Bottlebrush Copolymer Micelles Unsal, Hande; Onbulak, Sebla; Calik, Filiz Macromolecules, Vol. 50, Issue 4 https://doi.org/10.1021/acs.macromol.6b02182	journal	February 2017
50th Anniversary Perspective : Block Polymers—Pure Potential Bates, Christopher M.; Bates, Frank S. Macromolecules, Vol. 50, Issue 1 https://doi.org/10.1021/acs.macromol.6b02355	journal	December 2016
Self-Assembled Structures of Giant Surfactants Exhibit a Remarkable Sensitivity on Chemical Compositions and Topologies for Tailoring Sub-10 nm Nanostructures Yue, Kan; Liu, Chang; Huang, Mingjun Macromolecules, Vol. 50, Issue 1 https://doi.org/10.1021/acs.macromol.6b02446	journal	December 2016
50th Anniversary Perspective : Functional Nanoparticles from the Solution Self-Assembly of Block Copolymers Tritschler, Ulrich; Pearce, Sam; Gwyther, Jessica Macromolecules, Vol. 50, Issue 9 https://doi.org/10.1021/acs.macromol.6b02767	journal	April 2017
Rapid and Quantitative De- tert -butylation for Poly(acrylic acid) Block Copolymers and Influence on Relaxation of Thermoassociated Transient Networks Filippov, Alexei D.; van Hees, Ilse A.; Fokkink, Remco Macromolecules, Vol. 51, Issue 20 https://doi.org/10.1021/acs.macromol.8b01440	journal	October 2018
Amphiphilic Bottlebrush Block Copolymers: Analysis of Aqueous Self-Assembly by Small-Angle Neutron Scattering and Surface Tension Measurements Alaboalirat, Mohammed; Qi, Luqing; Arrington, Kyle J. Macromolecules, Vol. 52, Issue 2 https://doi.org/10.1021/acs.macromol.8b02366	journal	December 2018
Engineering of Molecular Geometry in Bottlebrush Polymers Walsh, Dylan J.; Dutta, Sarit; Sing, Charles E. Macromolecules, Vol. 52, Issue 13 https://doi.org/10.1021/acs.macromol.9b00845	journal	June 2019
Self-Assembly of Bottlebrush Block Copolymers into Triply Periodic Nanostructures in a Dilute Solution Ma, Hyunji; Kim, Kyoung Taek Macromolecules, Vol. 53, Issue 2 https://doi.org/10.1021/acs.macromol.9b01662	journal	January 2020
Experimental and Computational Evaluation of Self-Assembled Morphologies in Diblock Janus Bottlebrush Copolymers Liu, Runze; Sun, Zehao; Huang, Hejin Nano Letters, Vol. 23, Issue 1 https://doi.org/10.1021/acs.nanolett.2c03927	journal	December 2022
Synthesis and Micellization of Bottlebrush Poloxamers Hassler, Joseph F.; Van Zee, Nicholas J.; Crabtree, Adelyn A. ACS Macro Letters, Vol. 11, Issue 4 https://doi.org/10.1021/acsmacrolett.2c00053	journal	March 2022
In Situ Monitoring of Block Copolymer Self-Assembly via Solvent Exchange through Controlled Dialysis with Light and Neutron Scattering Detection Fauquignon, Martin; Porcar, Lionel; Brûlet, Annie ACS Macro Letters, Vol. 12, Issue 9 https://doi.org/10.1021/acsmacrolett.3c00286	journal	September 2023
Tapered Bottlebrush Polymers: Cone-Shaped Nanostructures by Sequential Addition of Macromonomers Radzinski, Scott C.; Foster, Jeffrey C.; Scannelli, Samantha J. ACS Macro Letters, Vol. 6, Issue 10 https://doi.org/10.1021/acsmacrolett.7b00724	journal	October 2017
Brush-Like Polymers and Entanglements: From Linear Chains to Filaments Liang, Heyi; Grest, Gary S.; Dobrynin, Andrey V. ACS Macro Letters, Vol. 8, Issue 10 https://doi.org/10.1021/acsmacrolett.9b00519	journal	September 2019
A Giant Surfactant of Polystyrene−(Carboxylic Acid-Functionalized Polyhedral Oligomeric Silsesquioxane) Amphiphile with Highly Stretched Polystyrene Tails in Micellar Assemblies Yu, Xinfei; Zhong, Sheng; Li, Xiaopeng Journal of the American Chemical Society, Vol. 132, Issue 47 https://doi.org/10.1021/ja1078305	journal	December 2010
Unusually Stable Aqueous Lyotropic Gyroid Phases from Gemini Dicarboxylate Surfactants Sorenson, Gregory P.; Coppage, Keiva L.; Mahanthappa, Mahesh K. Journal of the American Chemical Society, Vol. 133, Issue 38 https://doi.org/10.1021/ja2063555	journal	September 2011
Aqueous Self-Assembly of Giant Bottlebrush Block Copolymer Surfactants as Shape-Tunable Building Blocks Fenyves, Ryan; Schmutz, Marc; Horner, Ian J. Journal of the American Chemical Society, Vol. 136, Issue 21 https://doi.org/10.1021/ja503283r	journal	May 2014
Rational Design of the First Spherical Supramolecular Dendrimers Self-Organized in a Novel Thermotropic Cubic Liquid-Crystalline Phase and the Determination of Their Shape by X-ray Analysis Balagurusamy, V. S. K.; Ungar, G.; Percec, V. Journal of the American Chemical Society, Vol. 119, Issue 7 https://doi.org/10.1021/ja963295i	journal	February 1997
Local Chain Feature Mandated Self-Assembly of Block Copolymers Gan, Zhanhui; Zhou, Dongdong; Ma, Zhuang Journal of the American Chemical Society, Vol. 145, Issue 1 https://doi.org/10.1021/jacs.2c10761	journal	December 2022
Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution Fielden, Stephen D. P. Journal of the American Chemical Society, Vol. 146, Issue 28 https://doi.org/10.1021/jacs.4c03314	journal	July 2024
Getting into Shape: Reflections on a New Generation of Cylindrical Nanostructures’ Self-Assembly Using Polymer Building Blocks Foster, Jeffrey C.; Varlas, Spyridon; Couturaud, Benoit Journal of the American Chemical Society, Vol. 141, Issue 7 https://doi.org/10.1021/jacs.8b08648	journal	January 2019
Dendronized Poly(2-oxazoline) Displays within only Five Monomer Repeat Units Liquid Quasicrystal, A15 and σ Frank–Kasper Phases Holerca, Marian N.; Sahoo, Dipankar; Partridge, Benjamin E. Journal of the American Chemical Society, Vol. 140, Issue 49 https://doi.org/10.1021/jacs.8b11103	journal	November 2018
Topologically Precise and Discrete Bottlebrush Polymers: Synthesis, Characterization, and Structure–Property Relationships Ogbonna, Nduka D.; Dearman, Michael; Cho, Cheng-Ta JACS Au, Vol. 2, Issue 4 https://doi.org/10.1021/jacsau.2c00010	journal	March 2022
Simulation Studies of the Self-Assembly of Cone-Shaped Particles Chen, Ting; Zhang, Zhenli; Glotzer, Sharon C. Langmuir, Vol. 23, Issue 12 https://doi.org/10.1021/la063755d	journal	May 2007
Lyotropic Phase Morphologies of Amphiphilic Block Copolymers Förster, S.; Berton, B.; Hentze, H. -P. Macromolecules, Vol. 34, Issue 13 https://doi.org/10.1021/ma001923h	journal	June 2001
Dynamics of Spontaneous Vesicle Formation in Dilute Solutions of Amphiphilic Diblock Copolymers He, Xuehao; Schmid, Friederike Macromolecules, Vol. 39, Issue 7 https://doi.org/10.1021/ma052536g	journal	March 2006
Multiple Morphologies of PAA-b-PSt Assemblies throughout RAFT Dispersion Polymerization of Styrene with PAA Macro-CTA He, Wei-Dong; Sun, Xiao-Li; Wan, Wen-Ming Macromolecules, Vol. 44, Issue 9 https://doi.org/10.1021/ma2000674	journal	April 2011
Small-Angle Neutron Scattering Analysis of Bottlebrush Polymers Prepared via Grafting-Through Polymerization Pesek, Stacy L.; Li, Xianyu; Hammouda, Boualem Macromolecules, Vol. 46, Issue 17 https://doi.org/10.1021/ma401246b	journal	August 2013
Block-Copolymer-Based Plasmonic Nanostructures Mistark, Peter A.; Park, Soojin; Yalcin, Sibel Ebru ACS Nano, Vol. 3, Issue 12 https://doi.org/10.1021/nn901245w	journal	November 2009
Anisotropy of building blocks and their assembly into complex structures Glotzer, Sharon C.; Solomon, Michael J. Nature Materials, Vol. 6, Issue 8, p. 557-562 https://doi.org/10.1038/nmat1949	journal	August 2007
Coarse-grained molecular dynamics integrated with convolutional neural network for comparing shapes of temperature sensitive bottlebrushes Joshi, Soumil Y.; Singh, Samrendra; Deshmukh, Sanket A. npj Computational Materials, Vol. 8, Issue 1 https://doi.org/10.1038/s41524-022-00725-7	journal	March 2022
Liquid–liquid phase separation during amphiphilic self-assembly Ianiro, Alessandro; Wu, Hanglong; van Rijt, Mark M. J. Nature Chemistry, Vol. 11, Issue 4 https://doi.org/10.1038/s41557-019-0210-4	journal	February 2019
Self-assembly of cyclic polymers Williams, Rebecca J.; Dove, Andrew P.; O'Reilly, Rachel K. Polymer Chemistry, Vol. 6, Issue 16 https://doi.org/10.1039/C5PY00081E	journal	January 2015
Self-assembly of luminescent triblock bottlebrush copolymers in solution Shao, Feng; Wang, Yonghui; Tonge, Christopher M. Polymer Chemistry, Vol. 11, Issue 5 https://doi.org/10.1039/C9PY01695C	journal	January 2020
Dilute solution structure of bottlebrush polymers Dutta, Sarit; Wade, Matthew A.; Walsh, Dylan J. Soft Matter, Vol. 15, Issue 14 https://doi.org/10.1039/C9SM00033J	journal	January 2019
Molecular dynamics simulation study of linear, bottlebrush, and star-like amphiphilic block polymer assembly in solution Wessels, Michiel G.; Jayaraman, Arthi Soft Matter, Vol. 15, Issue 19 https://doi.org/10.1039/C9SM00375D	journal	January 2019
Self-assembly of giant bottlebrush block copolymer surfactants from luminescent organic electronic materials Wang, Yonghui; Shao, Feng; Sauvé, Ethan R. Soft Matter, Vol. 15, Issue 27 https://doi.org/10.1039/C9SM00931K	journal	January 2019
Kinetically-arrested single-polymer nanostructures from amphiphilic mikto-grafted bottlebrushes in solution: a simulation study Gumus, Bahar; Herrera-Alonso, Margarita; Ramírez-Hernández, Abelardo Soft Matter, Vol. 16, Issue 21 https://doi.org/10.1039/D0SM00771D	journal	January 2020
Radical–radical coupling effects in the direct-growth grafting-through synthesis of bottlebrush polymers using RAFT and ROMP Alaboalirat, Mohammed; Vu, Clark; Matson, John B. Polymer Chemistry, Vol. 13, Issue 41 https://doi.org/10.1039/D2PY00794K	journal	January 2022
Topological transformation of aggregates formed by an amphiphilic and truncated-cone-shaped codendrimer Yuan, Fei; Zhang, Xinjun; Yang, Miao Soft Matter, Vol. 3, Issue 11 https://doi.org/10.1039/b709705k	journal	January 2007
Synthesis and assembly of structured colloidal particles Yang, Seung-Man; Kim, Shin-Hyun; Lim, Jong-Min Journal of Materials Chemistry, Vol. 18, Issue 19 https://doi.org/10.1039/b716393b	journal	January 2008
Self-assembly of block copolymers Mai, Yiyong; Eisenberg, Adi Chemical Society Reviews, Vol. 41, Issue 18 https://doi.org/10.1039/c2cs35115c	journal	January 2012
Engineering shape: the novel geometries of colloidal self-assembly Sacanna, Stefano; Pine, David J.; Yi, Gi-Ra Soft Matter, Vol. 9, Issue 34 https://doi.org/10.1039/c3sm50500f	journal	January 2013
Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers Israelachvili, Jacob N.; Mitchell, D. John; Ninham, Barry W. Journal of the Chemical Society, Faraday Transactions 2, Vol. 72 https://doi.org/10.1039/f29767201525	journal	January 1976
Macromolecules with programmable shape, size, and chemistry Walsh, Dylan J.; Guironnet, Damien Proceedings of the National Academy of Sciences, Vol. 116, Issue 5 https://doi.org/10.1073/pnas.1817745116	journal	January 2019
Block Copolymer Assembly via Kinetic Control Cui, H.; Chen, Z.; Zhong, S. Science, Vol. 317, Issue 5838 https://doi.org/10.1126/science.1141768	journal	August 2007
Direct Visualization of Individual Cylindrical and Spherical Supramolecular Dendrimers Hudson, S. D. Science, Vol. 278, Issue 5337 https://doi.org/10.1126/science.278.5337.449	journal	October 1997
Recent trends in the tuning of polymersomes’ membrane properties Le Meins, J. -F.; Sandre, O.; Lecommandoux, S. The European Physical Journal E, Vol. 34, Issue 2 https://doi.org/10.1140/epje/i2011-11014-y	journal	February 2011
Polymersomes Discher, Dennis E.; Ahmed, Fariyal Annual Review of Biomedical Engineering, Vol. 8, Issue 1 https://doi.org/10.1146/annurev.bioeng.8.061505.095838	journal	August 2006
Block Copolymers: Synthesis, Self-Assembly, and Applications Feng, Hongbo; Lu, Xinyi; Wang, Weiyu Polymers, Vol. 9, Issue 12 https://doi.org/10.3390/polym9100494	journal	October 2017

Similar Records

Amphiphilic Bottlebrush Block Copolymers: Analysis of Aqueous Self-Assembly by Small-Angle Neutron Scattering and Surface Tension Measurements

Journal Article · Sun Dec 30 19:00:00 EST 2018 · Macromolecules · OSTI ID:1489558

Solution Structure and Scaling Laws of Cylindrical and Tapered Bottlebrush Polymers

Journal Article · Wed Nov 08 19:00:00 EST 2023 · Macromolecules · OSTI ID:2217703

Morphological Behavior of Compositionally Gradient Polystyrene–Polylactide Bottlebrush Copolymers

Journal Article · Mon Oct 21 20:00:00 EDT 2019 · Macromolecules · OSTI ID:1579894

Related Subjects

Atom-transfer radical polymerization
Cryo-electron tomography
Grubbs third generation catalyst
Semi-vesicles
Size exclusion chromatography with multi-angle light scattering

Aqueous Self‐Assembly of Cylindrical and Tapered Bottlebrush Block Copolymers

Citation Formats

References (75)

Similar Records

Related Subjects