Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice

Campbell, Matthew D.; Martín-Pérez, Miguel; Egertson, Jarrett D.; Gaffrey, Matthew J.; Wang, Lu; Bammler, Theo; Rabinovitch, Peter S.; MacCoss, Michael; Qian, Wei-Jun; Villen, Judit; Marcinek, David

doi:10.1007/s11357-022-00679-0

Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice

Journal Article · Wed Nov 02 00:00:00 EDT 2022 · GeroScience

DOI:https://doi.org/10.1007/s11357-022-00679-0· OSTI ID:2572566

Campbell, Matthew D. ^[1]; Martín-Pérez, Miguel ^[1]; Egertson, Jarrett D. ^[1]; Gaffrey, Matthew J. ^[2]; Wang, Lu ^[1]; Bammler, Theo ^[1]; Rabinovitch, Peter S. ^[1]; MacCoss, Michael ^[1]; ^[2]; Villen, Judit ^[1]; ^[1]

Univ. of Washington, Seattle, WA (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

The age-related decline in skeletal muscle mass and function is known as sarcopenia. Sarcopenia progresses based on complex processes involving protein dynamics, cell signaling, oxidative stress, and repair. We have previously found that 8-week treatment with elamipretide improves skeletal muscle function, reverses redox stress, and restores protein S-glutathionylation changes in aged female mice. This study tested whether 8-week treatment with elamipretide also affects global phosphorylation in skeletal muscle consistent with functional improvements and S-glutathionylation. Using female 6–7-month-old mice and 28–29-month-old mice, we found that phosphorylation changes did not relate to S-glutathionylation modifications, but that treatment with elamipretide did partially reverse age-related changes in protein phosphorylation in mouse skeletal muscle.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE; University of Washington

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2572566

Alternate ID(s):: OSTI ID: 2471538

Report Number(s):: PNNL-SA--179731; PII: 679

Journal Information:: GeroScience, Journal Name: GeroScience Journal Issue: 6 Vol. 44; ISSN 2509-2723; ISSN 2509-2715

Publisher:: Springer - American Aging Association (AGE)Copyright Statement

Country of Publication:: United States

Language:: English

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