A hierarchal model for bacterial cell inactivation in solution by direct and indirect treatment using cold atmospheric plasmas

Polito, Jordyn; Kushner, Mark J

doi:10.1088/1361-6463/ad5f3b

A hierarchal model for bacterial cell inactivation in solution by direct and indirect treatment using cold atmospheric plasmas

Journal Article · Fri Jul 19 00:00:00 EDT 2024 · Journal of Physics. D, Applied Physics

DOI:https://doi.org/10.1088/1361-6463/ad5f3b· OSTI ID:2572039

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University of Michigan, Ann Arbor, MI (United States)

Cold atmospheric plasma devices have shown promise for a variety of plasma medical applications, including wound healing and bacterial inactivation often performed in liquids. In the latter application, plasma-produced reactive oxygen and nitrogen species (RONS) interact with and damage bacterial cells, though the exact mechanism by which cell damage occurs is unclear. Computational models can help elucidate relationships between plasma-produced RONS and cell killing by enabling direct comparison between dissimilar plasma devices and by examining the effects of changing operating parameters in these devices. In biological applications, computational models of plasma-liquid interactions would be most effective in design and optimization of plasma devices if there is a corresponding prediction of the biological outcome. In this work, we propose a hierarchal model for planktonic bacterial cell inactivation by plasma produced RONS in liquid. A previously developed reaction mechanism for plasma induced modification of cysteine was extended to provide a basis for cell killing by plasma-produced RONS. Results from the model are compared to literature values to provide proof of concept. Differences in time to bacterial inactivation as a function of plasma operating parameters including gas composition and plasma source configuration are discussed. Results indicate that optimizing gas-phase reactive nitrogen species production may be key in the design of plasma devices for disinfection.

View Accepted Manuscript (DOE)

Research Organization:: University of Michigan, Ann Arbor, MI (United States)

Sponsoring Organization:: U.S. National Science Foundation (NSF); USDOE Office of Science (SC), Fusion Energy Sciences (FES)

Grant/Contract Number:: SC0020232

OSTI ID:: 2572039

Journal Information:: Journal of Physics. D, Applied Physics, Journal Name: Journal of Physics. D, Applied Physics Journal Issue: 40 Vol. 57; ISSN 0022-3727; ISSN 1361-6463

Publisher:: IOP PublishingCopyright Statement

Country of Publication:: United States

Language:: English

References (42)

Growth and Maintenance of Escherichia coli Laboratory Strains Tuttle, Amie R.; Trahan, Nicholas D.; Son, Mike S. Current Protocols, Vol. 1, Issue 1 https://doi.org/10.1002/cpz1.20	journal	January 2021
Reactive Species from Cold Atmospheric Plasma: Implications for Cancer Therapy: Reactive Species from Cold Atmospheric Plasma Graves, David B. Plasma Processes and Polymers, Vol. 11, Issue 12 https://doi.org/10.1002/ppap.201400068	journal	August 2014
Inactivation of microbes and macromolecules by atmospheric-pressure plasma jets Lackmann, Jan-Wilm; Bandow, Julia Elisabeth Applied Microbiology and Biotechnology, Vol. 98, Issue 14 https://doi.org/10.1007/s00253-014-5781-9	journal	May 2014
Technical applications of plasma treatments: current state and perspectives Šimončicová, Juliana; Kryštofová, Svetlana; Medvecká, Veronika Applied Microbiology and Biotechnology, Vol. 103, Issue 13 https://doi.org/10.1007/s00253-019-09877-x	journal	May 2019
Antibacterial and safety tests of a flexible cold atmospheric plasma device for the stimulation of wound healing Boekema, Bouke; Stoop, Matthea; Vlig, Marcel Applied Microbiology and Biotechnology, Vol. 105, Issue 5 https://doi.org/10.1007/s00253-021-11166-5	journal	February 2021
Mechanisms of bacterial inhibition and tolerance around cold atmospheric plasma Zhang, Hao; Zhang, Chengxi; Han, Qi Applied Microbiology and Biotechnology, Vol. 107, Issue 17 https://doi.org/10.1007/s00253-023-12618-w	journal	July 2023
The interplay between biological and physical scenarios of bacterial death induced by non-thermal plasma Lunov, Oleg; Zablotskii, Vitalii; Churpita, Olexander Biomaterials, Vol. 82 https://doi.org/10.1016/j.biomaterials.2015.12.027	journal	March 2016
Nonthermal plasma — A tool for decontamination and disinfection Scholtz, Vladimir; Pazlarova, Jarmila; Souskova, Hana Biotechnology Advances, Vol. 33, Issue 6 https://doi.org/10.1016/j.biotechadv.2015.01.002	journal	November 2015
Cold atmospheric plasma is bactericidal to wound-relevant pathogens and is compatible with burn wound healing Oliver, Mary A.; Hussein, Lou’ay K.; Molina, Esteban A. Burns, Vol. 50, Issue 5 https://doi.org/10.1016/j.burns.2023.12.012	journal	June 2024
Suitability of tissue tolerable plasmas (TTP) for the management of chronic wounds Kramer, A.; Lademann, J.; Bender, C. Clinical Plasma Medicine, Vol. 1, Issue 1 https://doi.org/10.1016/j.cpme.2013.03.002	journal	June 2013
The plasma jet kINPen – A powerful tool for wound healing Bekeschus, Sander; Schmidt, Anke; Weltmann, Klaus-Dieter Clinical Plasma Medicine, Vol. 4, Issue 1 https://doi.org/10.1016/j.cpme.2016.01.001	journal	July 2016
Cold physical plasma-induced oxidation of cysteine yields reactive sulfur species (RSS) Bruno, Giuliana; Heusler, Thea; Lackmann, Jan-Wilm Clinical Plasma Medicine, Vol. 14 https://doi.org/10.1016/j.cpme.2019.100083	journal	June 2019
An indoor air purification technology using a non-thermal plasma reactor with multiple-wire-to-wire type electrodes and a fiber air filter Jung, Jae-Seung; Kim, Jin-Gyu Journal of Electrostatics, Vol. 86 https://doi.org/10.1016/j.elstat.2016.12.011	journal	April 2017
Atmospheric pressure plasmas: Infection control and bacterial responses Mai-Prochnow, Anne; Murphy, Anthony B.; McLean, Keith M. International Journal of Antimicrobial Agents, Vol. 43, Issue 6 https://doi.org/10.1016/j.ijantimicag.2014.01.025	journal	June 2014
The inactivation and destruction of viruses by reactive oxygen species generated through physical and cold atmospheric plasma techniques: Current status and perspectives Kaushik, Neha; Mitra, Sarmistha; Baek, Eun Jung Journal of Advanced Research, Vol. 43 https://doi.org/10.1016/j.jare.2022.03.002	journal	January 2023
Non-thermal atmospheric pressure plasma jet for the bacterial inactivation in an aqueous medium Chandana, L.; Sangeetha, C. J.; Shashidhar, T. Science of The Total Environment, Vol. 640-641 https://doi.org/10.1016/j.scitotenv.2018.05.342	journal	November 2018
Chemical fingerprints of cold physical plasmas – an experimental and computational study using cysteine as tracer compound Lackmann, J. -W.; Wende, K.; Verlackt, C. Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-25937-0	journal	May 2018
CAP modifies the structure of a model protein from thermophilic bacteria: mechanisms of CAP-mediated inactivation Attri, Pankaj; Han, Jeongmin; Choi, Sooho Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-28600-w	journal	July 2018
Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species Nicol, McKayla J.; Brubaker, Timothy R.; Honish, Brian J. Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-59652-6	journal	February 2020
Synergistic Effect of H2O2 and NO2 in Cell Death Induced by Cold Atmospheric He Plasma Girard, Pierre-Marie; Arbabian, Atousa; Fleury, Michel Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep29098	journal	July 2016
Global model of plasma‐activated water over long time scale: Pulsed discharge and afterglow Ning, Wenjun; Shang, Hao; Ji, Yiwei High Voltage, Vol. 8, Issue 2 https://doi.org/10.1049/hve2.12248	journal	September 2022
Cold atmospheric plasma in cancer therapy Keidar, Michael; Shashurin, Alex; Volotskova, Olga Physics of Plasmas, Vol. 20, Issue 5 https://doi.org/10.1063/1.4801516	journal	May 2013
Non-thermal plasma mills bacteria: Scanning electron microscopy observations Lunov, O.; Churpita, O.; Zablotskii, V. Applied Physics Letters, Vol. 106, Issue 5 https://doi.org/10.1063/1.4907624	journal	February 2015
Interrogating the Escherichia coli cell cycle by cell dimension perturbations Zheng, Hai; Ho, Po-Yi; Jiang, Meiling Proceedings of the National Academy of Sciences, Vol. 113, Issue 52 https://doi.org/10.1073/pnas.1617932114	journal	December 2016
Mechanisms of bacterial inactivation in the liquid phase induced by a remote RF cold atmospheric pressure plasma jet van Gils, C. A. J.; Hofmann, S.; Boekema, B. K. H. L. Journal of Physics D: Applied Physics, Vol. 46, Issue 17 https://doi.org/10.1088/0022-3727/46/17/175203	journal	April 2013
Air plasma treatment of liquid covered tissue: long timescale chemistry Lietz, Amanda M.; Kushner, Mark J. Journal of Physics D: Applied Physics, Vol. 49, Issue 42 https://doi.org/10.1088/0022-3727/49/42/425204	journal	September 2016
Concepts and characteristics of the ‘COST Reference Microplasma Jet’ Golda, J.; Held, J.; Redeker, B. Journal of Physics D: Applied Physics, Vol. 49, Issue 8 https://doi.org/10.1088/0022-3727/49/8/084003	journal	January 2016
Global model of low-temperature atmospheric-pressure He + H ₂ O plasmas Liu, D. X.; Bruggeman, P.; Iza, F. Plasma Sources Science and Technology, Vol. 19, Issue 2 https://doi.org/10.1088/0963-0252/19/2/025018	journal	March 2010
Effect of water vapor on plasma morphology, OH and H ₂ O ₂ production in He and Ar atmospheric pressure dielectric barrier discharges Du, Yanjun; Nayak, Gaurav; Oinuma, Gaku Journal of Physics D: Applied Physics, Vol. 50, Issue 14 https://doi.org/10.1088/1361-6463/aa5e7d	journal	March 2017
The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications Reuter, Stephan; von Woedtke, Thomas; Weltmann, Klaus-Dieter Journal of Physics D: Applied Physics, Vol. 51, Issue 23 https://doi.org/10.1088/1361-6463/aab3ad	journal	May 2018
Atmospheric pressure plasma activation of water droplets Kruszelnicki, Juliusz; Lietz, Amanda M.; Kushner, Mark J. Journal of Physics D: Applied Physics, Vol. 52, Issue 35 https://doi.org/10.1088/1361-6463/ab25dc	journal	July 2019
Atomic oxygen density determination in the effluent of the COST reference source using in situ effective lifetime measurements in the presence of a liquid interface Myers, Brayden; Barnat, Edward; Stapelmann, Katharina Journal of Physics D: Applied Physics, Vol. 54, Issue 45 https://doi.org/10.1088/1361-6463/ac1cb5	journal	August 2021
Reaction mechanism for atmospheric pressure plasma treatment of cysteine in solution Polito, Jordyn; Herrera Quesada, María J.; Stapelmann, Katharina Journal of Physics D: Applied Physics, Vol. 56, Issue 39 https://doi.org/10.1088/1361-6463/ace196	journal	July 2023
Review of Plasma Technologies for Contribution of Environmental Purification Urashima, Kuniko IEEE Open Journal of Nanotechnology, Vol. 3 https://doi.org/10.1109/OJNANO.2022.3223897	journal	January 2022
Physical Mechanisms of Inactivation of Bacillus subtilis Spores Using Cold Atmospheric Plasmas Deng, X.; Shi, J.; Kong, M. G. IEEE Transactions on Plasma Science, Vol. 34, Issue 4 https://doi.org/10.1109/TPS.2006.877739	journal	August 2006
The Effects of Temperature and pH on the Growth of Eight Enteric and Nine Glucose Non‐Fermenting Species of Gram‐Negative Rods Tsuji, Akiyoshi; Kaneko, Yasuko; Takahashi, Kuniko Microbiology and Immunology, Vol. 26, Issue 1 https://doi.org/10.1111/j.1348-0421.1982.tb00149.x	journal	January 1982
Plasma jet's shielding gas impact on bacterial inactivation Jablonowski, Helena; Hänsch, Mareike A. Ch.; Dünnbier, Mario Biointerphases, Vol. 10, Issue 2 https://doi.org/10.1116/1.4916533	journal	June 2015
Cold Atmospheric Plasma (CAP) Changes Gene Expression of Key Molecules of the Wound Healing Machinery and Improves Wound Healing In Vitro and In Vivo Arndt, Stephanie; Unger, Petra; Wacker, Eva PLoS ONE, Vol. 8, Issue 11 https://doi.org/10.1371/journal.pone.0079325	journal	November 2013
Bactericidal Efficacy of Cold Atmospheric Plasma Treatment against Multidrug-Resistant Pseudomonas Aeruginosa Wang, Liyun; Xia, Chuankai; Guo, Yajun Future Microbiology, Vol. 15, Issue 2 https://doi.org/10.2217/fmb-2019-0265	journal	January 2020
Disinfection and Sterilization Using Plasma Technology: Fundamentals and Future Perspectives for Biological Applications Sakudo, Akikazu; Yagyu, Yoshihito; Onodera, Takashi International Journal of Molecular Sciences, Vol. 20, Issue 20 https://doi.org/10.3390/ijms20205216	journal	October 2019
Direct and Indirect Bactericidal Effects of Cold Atmospheric-Pressure Microplasma and Plasma Jet Yahaya, Ahmad Guji; Okuyama, Tomohiro; Kristof, Jaroslav Molecules, Vol. 26, Issue 9 https://doi.org/10.3390/molecules26092523	journal	April 2021
Inclusion of Biological Targets in the Analysis of Electrical Characteristics of Non-Thermal Plasma Discharge Sutter, Julia; Brettschneider, Jascha; Mamchur, Sara Plasma, Vol. 6, Issue 3 https://doi.org/10.3390/plasma6030040	journal	September 2023

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59 BASIC BIOLOGICAL SCIENCES
70 PLASMA PHYSICS AND FUSION TECHNOLOGY
atmospheric pressure plasma
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A hierarchal model for bacterial cell inactivation in solution by direct and indirect treatment using cold atmospheric plasmas

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