SCNN1, an epithelial cell sodium channel gene in the conserved linkage group on mouse chromosome 6 and human chromosome 12

Journal Article · Mon Oct 31 23:00:00 EST 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1599· OSTI ID:255228

Meisler, M H; Barrow, L L ^[1]; Canessa, C M ^[2]

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1. Univ. of Michigan, Ann Arbor, MI (United States)
2. Institut de Pharmacologie et de Toxicologie de l`Universitie, Lausanne (Switzerland); and others

SCNN1, a gene encoding a nonvoltage-gated sodium channel, was detected using a rat colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse SCNN1 was mapped to a conserved linkage group on distal chromosome 6. The observed order of mouse genes was centromere-Raf1-(2.1 {plus_minus} 2.1)Scnn1, Vwf-(1.9 {plus_minus} 1.9)-Ntf3, with 0/101 recombinants between Scnn1 and Vwf. No rearrangements of genomic DNA were detected in the linked mouse mutations deaf waddler (dfw) and opisthotonus (opt). 10 refs., 1 fig.

• OSTI ID: 255228
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 24; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENE MUTATIONS
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 12
PORINS