Physical localization of microsatellite markers at the ataxia-telangiectasia locus at 11q22-q23
- Tel Aviv Univ. (Israel); and others
The autosomal recessive disorder ataxia-telangiectasia (A-T) is genetically heterogeneous, with four complementation groups. The genes for the two major groups (ATA and ATC) have been mapped to 11q22-q23. Genetic analysis of the disease has been conducted to date using biallelic polymorphisms. The authors have physically mapped to this region eight new microsatellite markers that were generated by three laboratories that construct whole-genome linkage maps. These markers should be valuable for refined localization and positional cloning of the A-T genes and for diagnostic purposes. The results demonstrate the value of integrating genetic and physical maps generated by different laboratories. 15 refs., 1 fig., 1 tab.
- OSTI ID:
- 255191
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 22; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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