Association analysis of a polymorphism of the monoamine oxidase B gene with Parkinson`s disease in a Japanese population

Journal Article · Mon Dec 18 00:00:00 EST 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600618· OSTI ID:254414

Morimoto, Yuji; Murayama, Nobuhiro; Kuwano, Akira; Kondo, Ikuko ^[1]

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1. Ehime Univ. School of Medicine, Tokyo (Japan); and others

The polymorphic allele of the monoamine oxidase B (MAO-B) gene detected by polymerase chain reaction (PCR) and single-stranded conformation polymorphism (SSCP) was associated with Parkinson`s disease (PD) in Caucasians. We characterized this polymorphic allele, allele 1, of the MAO-B gene using direct sequencing of PCR products. A single DNA substitution (G-A), resulting gain of Mae III restriction site was detected in intron 13 of the MAO-B gene. The allele associated with PD in Caucasians was twice as frequent as in healthy Japanese, but the association of the allele of the MAO-B gene was not observed in Japanese patients with PD. 7 refs., 2 figs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 254414
• Journal Information: American Journal of Medical Genetics, Vol. 60, Issue 6; Other Information: PBD: 18 Dec 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
GENE MUTATIONS
DNA SEQUENCING
PATIENTS
NERVOUS SYSTEM DISEASES
DISEASE INCIDENCE
HEREDITARY DISEASES
JAPAN
DETECTION
OXIDOREDUCTASES
STATISTICS
POLYMERASE CHAIN REACTION
INTRONS