Failure to find a chromosome 18 pericentric linkage in families with schizophrenia
Journal Article
·
· American Journal of Medical Genetics
- SUNY Stony Brook, NY (United States)
- Columbia Univ. and New York State Psychiatric Institute, New York, NY (United States); and others
A recent report of a possible linkage of bipolar affective disorder to a pericentric region of chromosome 18 initiated the present investigation to search for a similar linkage in 32 families with schizophrenia. The results of a study using 5 markers mapped to this region show negative lod scores and only weak evidence for any linkage by nonparametric analyses. If the previously reported finding is a true positive linkage for bipolar disorder, then either it is unlikely to be related to the genetics of schizophrenia, or the proportion of families linked to this region is small. 12 refs., 4 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 254407
- Journal Information:
- American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 6 Vol. 60; ISSN 0148-7299; ISSN AJMGDA
- Country of Publication:
- United States
- Language:
- English
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