Association study of schizophrenia and IL-2 receptor {beta} chain gene

Journal Article · Mon Oct 09 00:00:00 EDT 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600517· OSTI ID:254391

Nimgaonkar, V L; Yang, Z W; Zhang, X R; Brar, J S ^[1]

---

1. Univ. of Pittsburgh School of Medicine, PA (United States); and others

A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2RP chain gene, were examined in both groups. No significant differences in IL-2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2RP gene locus, contrary to the suggestive evidence from linkage analysis in multicase families. 17 refs., 2 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 254391
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 5 Vol. 60; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
ETIOLOGY
GENE MUTATIONS
GENES
GENETIC MAPPING
GENETICS
HUMAN CHROMOSOME 22
LYMPHOKINES
MENTAL DISORDERS
NUCLEOTIDES
PATIENTS
RECEPTORS
STATISTICS