Risk of longer-term endocrine and metabolic conditions in the Deepwater Horizon Oil Spill Coast Guard cohort study – five years of follow-up

Denic-Roberts, Hristina; Engel, Lawrence S.; Buchanich, Jeanine M.; Miller, Rachel G.; Talbott, Evelyn O.; Thomas, Dana L.; McAdam, Jordan; Emerick, Jill E.; Costacou, Tina; Rusiecki, Jennifer A.

doi:10.1186/s12940-025-01164-9

Risk of longer-term endocrine and metabolic conditions in the Deepwater Horizon Oil Spill Coast Guard cohort study – five years of follow-up

Journal Article · Sat Mar 22 00:00:00 EDT 2025 · Environmental Health

DOI:https://doi.org/10.1186/s12940-025-01164-9· OSTI ID:2536739

Denic-Roberts, Hristina; Engel, Lawrence S.; Buchanich, Jeanine M.; Miller, Rachel G.; Talbott, Evelyn O.; Thomas, Dana L.; McAdam, Jordan; Emerick, Jill E.; Costacou, Tina; Rusiecki, Jennifer A.

Abstract Introduction

Long-term endocrine and metabolic health risks associated with oil spill cleanup exposures are largely unknown, despite the endocrine-disrupting potential of crude oil and oil dispersant constituents. We aimed to investigate risks of longer-term endocrine and metabolic conditions among U.S. Coast Guard (USCG) responders to the Deepwater Horizon (DWH) oil spill.

Methods

Our study population included all active duty DWH Oil Spill Coast Guard Cohort members ( N = 45,224). Self-reported spill exposures were ascertained from post-deployment surveys. Incident endocrine and metabolic outcomes were defined using International Classification of Diseases (9th Revision) diagnostic codes from military health encounter records up to 5.5 years post-DWH. Using Cox proportional hazards regression, we estimated adjusted hazard ratios (aHR) and 95% confidence intervals (CIs) for various incident endocrine and metabolic diagnoses (2010–2015, and separately during 2010–2012 and 2013–2015).

Results

The mean baseline age was 30 years (~ 77% white, ~ 86% male). Compared to non-responders ( n = 39,260), spill responders ( n = 5,964) had elevated risks for simple and unspecified goiter (aHR = 2.09, 95% CI: 1.29–3.38) and disorders of lipid metabolism (aHR = 1.09, 95% CI: 1.00–1.18), including its subcategory other and unspecified hyperlipidemia (aHR = 1.10, 95% CI: 1.01–1.21). The dysmetabolic syndrome X risk was elevated only during 2010–2012 (aHR = 2.07, 95% CI: 1.22–3.51). Responders reporting ever ( n = 1,068) vs. never ( n = 2,424) crude oil inhalation exposure had elevated risks for disorders of lipid metabolism (aHR = 1.24, 95% CI: 1.00–1.53), including its subcategory pure hypercholesterolemia (aHR = 1.71, 95% CI: 1.08–2.72), the overweight, obesity and other hyperalimentation subcategory of unspecified obesity (aHR = 1.52, 95% CI: 1.09–2.13), and abnormal weight gain (aHR = 2.60, 95% CI: 1.04–6.55). Risk estimates for endocrine/metabolic conditions were generally stronger among responders reporting exposure to both crude oil and dispersants (vs. neither) than among responders reporting only oil exposure (vs. neither).

Conclusion

In this large cohort of active duty USCG responders to the DWH disaster, oil spill cleanup exposures were associated with elevated risks for longer-term endocrine and metabolic conditions.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0014664

OSTI ID:: 2536739

Journal Information:: Environmental Health, Journal Name: Environmental Health Journal Issue: 1 Vol. 24; ISSN 1476-069X

Publisher:: Springer Science + Business MediaCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (56)

Trends in Obesity and Severe Obesity Prevalence in US Youth and Adults by Sex and Age, 2007-2008 to 2015-2016 Hales, Craig M.; Fryar, Cheryl D.; Carroll, Margaret D. JAMA, Vol. 319, Issue 16 https://doi.org/10.1001/jama.2018.3060	journal	April 2018
An evaluation of the endocrine disruptive potential of crude oil water accommodated fractions and crude oil contaminated surface water to freshwater organisms using in vitro and in vivo approaches Truter, J. Christoff; van Wyk, Johannes H.; Oberholster, Paul J. Environmental Toxicology and Chemistry, Vol. 36, Issue 5 https://doi.org/10.1002/etc.3665	journal	October 2016
Risk factors for acute mental health symptoms and tobacco initiation in Coast Guard Responders to the Deepwater Horizon oil spill Wang, Jeanny H.; Denic‐Roberts, Hristina; Goodie, Jeffrey L. Journal of Traumatic Stress, Vol. 35, Issue 4 https://doi.org/10.1002/jts.22817	journal	March 2022
Endocrinology of Physical Activity and Sport Hackney, Anthony C.; Constantini, Naama W. Contemporary Endocrinology https://doi.org/10.1007/978-3-030-33376-8	book	January 2020
Tobacco Smoking as an EDC in Metabolic Disorders Jabeen, Komal; Akash, Muhammad Sajid Hamid; Haider, Kamran Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies https://doi.org/10.1007/978-3-030-45923-9_20	book	August 2020
Oxidative stress in two tropical species after exposure to diesel oil Sardi, Adriana E.; Sandrini-Neto, Leonardo; da S. Pereira, Leticia Environmental Science and Pollution Research, Vol. 23, Issue 20 https://doi.org/10.1007/s11356-016-7280-2	journal	August 2016
Stress and Obesity: Are There More Susceptible Individuals? van der Valk, Eline S.; Savas, Mesut; van Rossum, Elisabeth F. C. Current Obesity Reports, Vol. 7, Issue 2 https://doi.org/10.1007/s13679-018-0306-y	journal	April 2018
Trend of nutrition research in endocrine disorders, gaps, and future plans: a collection of experiences of an endocrinology research institute Namazi, Nazli; Atlasi, Rasha; Aletaha, Azadeh Journal of Diabetes & Metabolic Disorders, Vol. 23, Issue 2 https://doi.org/10.1007/s40200-020-00707-w	journal	January 2021
Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist Barrea, L.; Verde, L.; Annunziata, G. Journal of Endocrinological Investigation, Vol. 47, Issue 1 https://doi.org/10.1007/s40618-023-02169-2	journal	September 2023
Metabolic and Endocrine Disorders and Exercise Felig, Philip Exercise Medicine https://doi.org/10.1016/B978-0-12-119720-9.50021-3	book	January 1983
Endocrine disorders associated with obesity Park, Hyeong-Kyu; Ahima, Rexford S. Best Practice & Research Clinical Obstetrics & Gynaecology, Vol. 90 https://doi.org/10.1016/j.bpobgyn.2023.102394	journal	August 2023
Relationship between blood concentrations of heavy metals and cytogenetic and endocrine parameters among subjects involved in cleaning coastal areas affected by the ‘Prestige’ tanker oil spill Pérez-Cadahía, Beatriz; Laffon, Blanca; Porta, Miquel Chemosphere, Vol. 71, Issue 3 https://doi.org/10.1016/j.chemosphere.2007.10.053	journal	March 2008
The interaction effects of smoking and polycyclic aromatic hydrocarbons exposure on the prevalence of metabolic syndrome in coke oven workers Zhang, Bin; Pan, Baolong; Zhao, Xinyu Chemosphere, Vol. 247 https://doi.org/10.1016/j.chemosphere.2020.125880	journal	May 2020
The association between internal polycyclic aromatic hydrocarbons exposure and risk of Obesity—A systematic review with meta-analysis Liu, Chunyu; Liu, Qisijing; Song, Shanjun Chemosphere, Vol. 329 https://doi.org/10.1016/j.chemosphere.2023.138669	journal	July 2023
An association between oil spill clean-up work and cardiovascular disease Lee, Mihye; Park, Myung-Sook; Cheong, Hae-Kwan Ecotoxicology and Environmental Safety, Vol. 194 https://doi.org/10.1016/j.ecoenv.2020.110284	journal	May 2020
Initial study on the effects of Prestige oil on human health Pérez-Cadahía, Beatriz; Lafuente, Anunciación; Cabaleiro, Teresa Environment International, Vol. 33, Issue 2 https://doi.org/10.1016/j.envint.2006.09.006	journal	February 2007
Endocrine and immunological parameters in individuals involved in Prestige spill cleanup tasks seven years after the exposure Laffon, Blanca; Aguilera, Francisco; Ríos-Vázquez, Julia Environment International, Vol. 59 https://doi.org/10.1016/j.envint.2013.05.014	journal	September 2013
Acute and longer-term cardiovascular conditions in the Deepwater Horizon Oil Spill Coast Guard Cohort Denic-Roberts, Hristina; Rowley, Nicole; Haigney, Mark C. Environment International, Vol. 158 https://doi.org/10.1016/j.envint.2021.106937	journal	January 2022
Longitudinal relationships of polycyclic aromatic hydrocarbons exposure and genetic susceptibility with blood lipid profiles Ma, Jixuan; Hao, Xingjie; Nie, Xiuquan Environment International, Vol. 164 https://doi.org/10.1016/j.envint.2022.107259	journal	June 2022
Association between urinary polycyclic aromatic hydrocarbon metabolites and dyslipidemias in the Chinese general population: A cross-sectional study Ma, Jixuan; Zhou, Yun; Liu, Yuewei Environmental Pollution, Vol. 245 https://doi.org/10.1016/j.envpol.2018.10.134	journal	February 2019
Dysregulation of lipid metabolism induced by airway exposure to polycyclic aromatic hydrocarbons in C57BL/6 mice Li, Fang; Xiang, Binbin; Jin, Yan Environmental Pollution, Vol. 245 https://doi.org/10.1016/j.envpol.2018.11.049	journal	February 2019
Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and risk of papillary thyroid carcinoma and nodular goiter: A case-control study in non-occupational populations Liu, Boying; Chen, Yanyan; Li, Siyao Environmental Pollution, Vol. 269 https://doi.org/10.1016/j.envpol.2020.116158	journal	January 2021
Self-reported myocardial infarction and fatal coronary heart disease among oil spill workers and community members 5 years after Deepwater Horizon Strelitz, Jean; Keil, Alexander P.; Richardson, David B. Environmental Research, Vol. 168 https://doi.org/10.1016/j.envres.2018.09.026	journal	January 2019
Traffic-related air pollution is associated with glucose dysregulation, blood pressure, and oxidative stress in children Mann, Jennifer K.; Lutzker, Liza; Holm, Stephanie M. Environmental Research, Vol. 195 https://doi.org/10.1016/j.envres.2021.110870	journal	April 2021
Associations between exposure to polycyclic aromatic hydrocarbons and metabolic syndrome in U.S. adolescents: Cross-sectional results from the National Health and Nutrition Examination Survey (2003–2016) data Li, Kun; Yin, Ruili; Wang, Yan Environmental Research, Vol. 202 https://doi.org/10.1016/j.envres.2021.111747	journal	November 2021
Incidence of chronic respiratory conditions among oil spill responders: Five years of follow-up in the Deepwater Horizon Oil Spill Coast Guard Cohort study Rusiecki, Jennifer A.; Denic-Roberts, Hristina; Thomas, Dana L. Environmental Research, Vol. 203 https://doi.org/10.1016/j.envres.2021.111824	journal	January 2022
The association between oil spill cleanup-related total hydrocarbon exposure and diabetes Jardel, H. V.; Engel, L. S.; Lawrence, K. G. Environmental Research, Vol. 212 https://doi.org/10.1016/j.envres.2022.113591	journal	September 2022
Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds is associated with a risk of obesity and diabetes mellitus among Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015–2017 Lee, Inae; Park, Hyunwoong; Kim, Min Joo International Journal of Hygiene and Environmental Health, Vol. 240 https://doi.org/10.1016/j.ijheh.2021.113886	journal	March 2022
Expression of microRNAs, CYP1A1 and CYP2B1 in the livers and ovaries of female rats treated with DDT and PAHs Chanyshev, M. D.; Kosorotikov, N. I.; Titov, S. E. Life Sciences, Vol. 103, Issue 2 https://doi.org/10.1016/j.lfs.2014.03.031	journal	May 2014
Evaluation of behavioral parameters, hematological markers, liver and kidney functions in rodents exposed to Deepwater Horizon crude oil and Corexit Ramesh, Sindhu; Bhattacharya, Dwipayan; Majrashi, Mohammed Life Sciences, Vol. 199 https://doi.org/10.1016/j.lfs.2018.02.028	journal	April 2018
Characterization of endocrine disruption potentials of coastal sediments of Taean, Korea employing H295R and MVLN assays–Reconnaissance at 5 years after Hebei Spirit oil spill Liu, Xiaoshan; Jung, Dawoon; Zhou, Kairu Marine Pollution Bulletin, Vol. 127 https://doi.org/10.1016/j.marpolbul.2017.11.055	journal	February 2018
Environmental polycyclic aromatic hydrocarbon exposure in relation to metabolic syndrome in US adults Yang, Xue; Xue, Qingping; Wen, Ying Science of The Total Environment, Vol. 840 https://doi.org/10.1016/j.scitotenv.2022.156673	journal	September 2022
The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers Bowers, Robert R.; Temkin, Alexis M.; Guillette, Louis J. General and Comparative Endocrinology, Vol. 238 https://doi.org/10.1016/j.ygcen.2016.04.029	journal	November 2016
Thyroid Hormone Disruption by Water-Accommodated Fractions of Crude Oil and Sediments Affected by the Hebei Spirit Oil Spill in Zebrafish and GH3 Cells Kim, Sujin; Sohn, Ju Hae; Ha, Sung Yong Environmental Science & Technology, Vol. 50, Issue 11 https://doi.org/10.1021/acs.est.6b00751	journal	May 2016
Early markers of cardiovascular disease are associated with occupational exposure to polycyclic aromatic hydrocarbons Alhamdow, Ayman; Lindh, Christian; Albin, Maria Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-09956-x	journal	August 2017
Increased adiposity, inflammation, metabolic disruption and dyslipidemia in adult male offspring of DOSS treated C57BL/6 dams Temkin, Alexis M.; Bowers, Robert R.; Ulmer, Candice Z. Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-018-38383-9	journal	February 2019
Endocrine disrupting potential of PAHs and their alkylated analogues associated with oil spills Lee, Sangwoo; Hong, Seongjin; Liu, Xiaoshan Environmental Science: Processes & Impacts, Vol. 19, Issue 9 https://doi.org/10.1039/C7EM00125H	journal	January 2017
The Gulf Oil Spill Goldstein, Bernard D.; Osofsky, Howard J.; Lichtveld, Maureen Y. New England Journal of Medicine, Vol. 364, Issue 14 https://doi.org/10.1056/NEJMra1007197	journal	April 2011
Plant-derived functional components: prevent from various disorders by regulating the endocrine glands Khalid, Waseem; Maqbool, Zahra; Arshad, Muhammad Sajid International Journal of Food Properties, Vol. 25, Issue 1 https://doi.org/10.1080/10942912.2022.2070643	journal	May 2022
Exposure to Total Hydrocarbons During Cleanup of the Deepwater Horizon Oil Spill and Risk of Heart Attack Across 5 Years of Follow-up Strelitz, Jean; Sandler, Dale P.; Keil, Alexander P. American Journal of Epidemiology, Vol. 188, Issue 5 https://doi.org/10.1093/aje/kwz017	journal	January 2019
Evaluation of Polycyclic Aromatic Hydrocarbons in the Activation of Early Growth Response-1 and Peroxisome Proliferator Activated Receptors Kim, Jeong-Ho; Yamaguchi, Kiyoshi; Lee, Seong-Ho Toxicological Sciences, Vol. 85, Issue 1 https://doi.org/10.1093/toxsci/kfi118	journal	February 2005
Measuring Diagnoses: ICD Code Accuracy O'Malley, Kimberly J.; Cook, Karon F.; Price, Matt D. Health Services Research, Vol. 40, Issue 5p2 https://doi.org/10.1111/j.1475-6773.2005.00444.x	journal	October 2005
Invisible oil beyond the Deepwater Horizon satellite footprint Berenshtein, Igal; Paris, Claire B.; Perlin, Natalie Science Advances, Vol. 6, Issue 7 https://doi.org/10.1126/sciadv.aaw8863	journal	February 2020
Magnitude of the 2010 Gulf of Mexico Oil Leak Crone, Timothy J.; Tolstoy, Maya Science, Vol. 330, Issue 6004 https://doi.org/10.1126/science.1195840	journal	September 2010
Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke Fowles, J. Tobacco Control, Vol. 12, Issue 4 https://doi.org/10.1136/tc.12.4.424	journal	December 2003
Weighing the odds: Assessing underdiagnosis of adult obesity via electronic medical record problem list omissions Kapoor, Akshat; Kim, Juhee; Zeng, Xiaoming DIGITAL HEALTH, Vol. 6 https://doi.org/10.1177/2055207620918715	journal	January 2020
Leveraging healthcare utilization to explore outcomes from musculoskeletal disorders: methodology for defining relevant variables from a health services data repository Rhon, Daniel I.; Clewley, Derek; Young, Jodi L. BMC Medical Informatics and Decision Making, Vol. 18, Issue 1 https://doi.org/10.1186/s12911-018-0588-8	journal	January 2018
Risk of longer-term neurological conditions in the Deepwater Horizon Oil Spill Coast Guard Cohort Study – Five years of follow-up Denic-Roberts, Hristina; Engel, Lawrence S.; Buchanich, Jeanine M. Environmental Health, Vol. 22, Issue 1 https://doi.org/10.1186/s12940-022-00941-0	journal	January 2023
Circulating Thyroid Hormones in Endemic Goiter Delange, F.; Camus, M.; Ermans, A. M. The Journal of Clinical Endocrinology & Metabolism, Vol. 34, Issue 5 https://doi.org/10.1210/jcem-34-5-891	journal	May 1972
Urinary Polycyclic Aromatic Hydrocarbons and Childhood Obesity: NHANES (2001–2006) Scinicariello, Franco; Buser, Melanie C. Environmental Health Perspectives, Vol. 122, Issue 3 https://doi.org/10.1289/ehp.1307234	journal	March 2014
Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPAR γ Activity in Vitro and in Vivo : Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen Temkin, Alexis M.; Bowers, Robert R.; Magaletta, Margaret E. Environmental Health Perspectives, Vol. 124, Issue 1 https://doi.org/10.1289/ehp.1409672	journal	January 2016
Smoking and hormones in health and endocrine disorders Kapoor, D.; Jones, T. H. European Journal of Endocrinology, Vol. 152, Issue 4 https://doi.org/10.1530/eje.1.01867	journal	April 2005
Oxidative Stress Poncin, Sylvie; Van Eeckoudt, Sandrine; Humblet, Kevin The American Journal of Pathology, Vol. 176, Issue 3 https://doi.org/10.2353/ajpath.2010.090682	journal	March 2010
Dietary Intake of Endocrine Disrupting Substances Presents in Environment and Their Impact on Thyroid Function Sokal, Aneta; Jarmakiewicz-Czaja, Sara; Tabarkiewicz, Jacek Nutrients, Vol. 13, Issue 3 https://doi.org/10.3390/nu13030867	journal	March 2021
Association of Urinary Benzene Metabolite and the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol: A Cross-Sectional Study Using the Korean National Environmental Health Survey (2018–2020) Baek, Seungju; Park, Eunjung; Park, Eun Young Toxics, Vol. 11, Issue 12 https://doi.org/10.3390/toxics11120985	journal	December 2023
The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases Xu, Xizhen; Li, Rui; Chen, Guangzhi Advances in Nutrition, Vol. 7, Issue 6 https://doi.org/10.3945/an.116.012245	journal	November 2016

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